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Here, we review mechanisms controlling the production and functions of interleukin\u201017 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017) and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201022, cytokines that direct several aspects of lung immunity. Innate lymphocytes (\u03b3\u03b4 T cells, natural killer cells, innate lymphoid cells) are the major source of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201022 during acute infections, while <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> T\u2010helper 17 (Th17) cells contribute to vaccine\u2010induced immunity. The characterization of dendritic cell (<jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>) subsets has revealed their central roles in T\u2010cell activation. <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>11b<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s stimulated with bacteria or fungi secrete <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023, potent inducers of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201022. On the other hand, recognition of viruses by plasmacytoid <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s inhibits <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023 release, increasing susceptibility to bacterial superinfections. <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201022 primarily act on the lung epithelium, inducing antimicrobial proteins and neutrophil chemoattractants. Recent studies found that stimulation of macrophages and <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s with <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 also contributes to antibacterial immunity, while <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201022 promotes epithelial proliferation and repair following injury. Chronic diseases such as asthma and chronic obstructive pulmonary disease have been associated with <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201022 responses directed against innocuous antigens. Future studies will evaluate the therapeutic efficacy of targeting the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017\/<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201022 pathway in pulmonary inflammation.<\/jats:p>","DOI":"10.1111\/imr.12183","type":"journal-article","created":{"date-parts":[[2014,6,19]],"date-time":"2014-06-19T05:56:42Z","timestamp":1403157402000},"page":"129-144","source":"Crossref","is-referenced-by-count":187,"title":["Directing traffic: <scp>IL<\/scp>\u201017 and <scp>IL<\/scp>\u201022 coordinate pulmonary immune defense"],"prefix":"10.1111","volume":"260","author":[{"given":"Jeremy P.","family":"McAleer","sequence":"first","affiliation":[{"name":"Richard King Mellon Foundation Institute for Pediatric Research Children's Hospital of Pittsburgh of UPMC Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay 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