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Currently, a PubMed search for \u2018adipose tissue inflammation\u2019 reveals over 3500 entries since these original reports. We now know that resident macrophages in lean <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content> are alternatively activated, M2\u2010like, and play a role in <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content> homeostasis. In contrast, the macrophages in obese <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content> are dramatically increased in number and are predominantly classically activated, M1\u2010like, and promote inflammation and insulin resistance. Mediators of <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content> macrophage (<jats:styled-content style=\"fixed-case\">ATM<\/jats:styled-content>) phenotype include adipokines and fatty acids secreted from adipocytes as well as cytokines secreted from other immune cells in <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>. There are several mechanisms that could explain the large increase in <jats:styled-content style=\"fixed-case\">ATM<\/jats:styled-content>s in obesity. These include recruitment\u2010dependent mechanisms such as adipocyte death, chemokine release, and lipolysis of fatty acids. Newer evidence also points to recruitment\u2010independent mechanisms such as impaired apoptosis, increased proliferation, and decreased egress. Although less is known about the homeostatic function of M2\u2010like resident <jats:styled-content style=\"fixed-case\">ATM<\/jats:styled-content>s, recent evidence suggests roles in <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content> expansion, thermoregulation, antigen presentation, and iron homeostasis. The field of immunometabolism has come a long way in the past decade, and many exciting new discoveries are bound to be made in the coming years that will expand our understanding of how <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content> stands at the junction of immune and metabolic co\u2010regulation.<\/jats:p>","DOI":"10.1111\/imr.12216","type":"journal-article","created":{"date-parts":[[2014,10,15]],"date-time":"2014-10-15T12:22:20Z","timestamp":1413375740000},"page":"134-152","source":"Crossref","is-referenced-by-count":207,"title":["A decade of progress in adipose tissue macrophage biology"],"prefix":"10.1111","volume":"262","author":[{"given":"Andrea A.","family":"Hill","sequence":"first","affiliation":[{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University School of Medicine Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Reid 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