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Despite the significant advances in treatment, <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> is still a fatal malignancy. This is mainly due to the supportive role of the <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> microenvironment in differentiation, migration, proliferation, survival, and drug resistance of the malignant plasma cells. The <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> microenvironment is composed of a cellular compartment (stromal cells, osteoblasts, osteoclasts, endothelial cells, and immune cells) and a non\u2010cellular compartment. 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