{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:48:56Z","timestamp":1792680536357,"version":"4.5.0"},"reference-count":143,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,2,20]],"date-time":"2015-02-20T00:00:00Z","timestamp":1424390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01AI111967-01 and 1R01AI106398-01"],"award-info":[{"award-number":["1R01AI111967-01 and 1R01AI106398-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN272201000009I\/01"],"award-info":[{"award-number":["HHSN272201000009I\/01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunological Reviews"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Tuberculosis (<jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>) lesions are extremely complex and dynamic. Here, we review the multiple types and fates of pulmonary lesions that form following infection by <jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ycobacterium tuberculosis<\/jats:italic> and the impact of this spatial and temporal heterogeneity on the bacteria they harbor. The diverse immunopathology of granulomas and cavities generates a plethora of microenvironments to which <jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>.\u00a0tuberculosis<\/jats:italic> bacilli must adapt. This in turn affects the replication, metabolism, and relative density of bacterial subpopulations, and consequently their respective susceptibility to chemotherapy. We outline recent developments that support a paradigm shift in our understanding of lesion progression. The simple model according to which lesions within a single individual react similarly to the systemic immune response no longer prevails. Host\u2010pathogen interactions within lesions are a dynamic process, driven by subtle and local differences in signaling pathways, resulting in diverging trajectories of lesions within a single host. The spectrum of <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> lesions is a continuum with a large overlap in the lesion types found in latently infected and active <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> patients. We hope this overview will guide <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> researchers in the design, choice of read\u2010outs, and interpretation of future studies in the search for predictive biomarkers and novel therapies.<\/jats:p>","DOI":"10.1111\/imr.12252","type":"journal-article","created":{"date-parts":[[2015,2,20]],"date-time":"2015-02-20T13:17:25Z","timestamp":1424438245000},"page":"288-307","source":"Crossref","is-referenced-by-count":382,"title":["Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses"],"prefix":"10.1111","volume":"264","author":[{"given":"Anne","family":"Lenaerts","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology and Pathology Colorado State University Ft. Collins CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Clifton E.","family":"Barry","sequence":"additional","affiliation":[{"name":"Tuberculosis Research Section Laboratory of Clinical Infectious Diseases NIH\u2010NIAID Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Dartois","sequence":"additional","affiliation":[{"name":"Public Health Research Institute New Jersey Medical School Rutgers, The State University of New Jersey Newark NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","DOI":"10.1525\/9780520915176","volume-title":"The Making of a Social Disease \u2013 Tuberculosis in Nineteenth\u2010Century France","author":"Barnes DS","year":"1995"},{"key":"e_1_2_12_3_1","volume-title":"The Tubercle Bacillus","author":"Canetti G","year":"1955"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/9781555815684"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00531-12"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00632-13"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/2191-219X-3-55"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.114.144634"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2013.0437"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/980594"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2236"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2009.02.005"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.10.5831-5844.2003"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00592-09"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09247"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070630"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1201964"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009500"},{"key":"e_1_2_12_19_1","first-page":"276","article-title":"Short term chemotherapy of tuberculosis. Factors affecting relapse following short term chemotherapy","volume":"53","author":"Aber VR","year":"1978","journal-title":"Bull Int Union Tuberc"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200407-905OC"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09742-8"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.150227197"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00217-12"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00789-09"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02565-14"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039680"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit152"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2013.09.004"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080669"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27271"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00277-13"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00079-10"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400676"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.10.6004-6011.2003"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2007.10.006"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.07.019"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.110016"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05208-11"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3412"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2013.06.007"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13489"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2387"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.02.013"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.12.023"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.01.026"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300113"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/1478-811X-11-60"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2009.01.005"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02837"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31097"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/158.2.366"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00140913"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.3.9705044"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-0903"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2011.10.003"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2012.01783.x"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3399"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.07.006"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110919"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3259"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2013.07.004"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1728"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006077"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608654104"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1998.01026.x"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1086\/378563"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011108"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(06)70578-3"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2014.07.004"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.1.546-551.2005"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12337"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.55.1.139"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.12.14"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2005.00612.x"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01515-07"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2055"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00276-07"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir786"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030205"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.64.6.2062-2069.1996"},{"key":"e_1_2_12_81_1","first-page":"3765","article-title":"Hypoxia and vascular endothelial growth factor expression in human squamous cell carcinomas using pimonidazole as a hypoxia marker","volume":"58","author":"Raleigh JA","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01779121"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002287"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201000079"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M505556200"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2007.07.003"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0711159105"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2011.01.001"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002093"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0050075"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01196-13"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002507"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409716102"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2005.10.007"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030846"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001403"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0306023101"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/35021159"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/35021074"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1252"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000715107"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.1.286-291.2002"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-2508(99)80055-2"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2000.01794.x"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.12.7099-7108.2003"},{"key":"e_1_2_12_106_1","first-page":"179","article-title":"Mechanism of softening of tubercles. III. Hydrolysis of protein and nucleic acid during anaerobic autolysis of normal and tuberculous lung tissue in vitro","volume":"57","author":"Weiss C","year":"1954","journal-title":"AMA Arch Pathol"},{"key":"e_1_2_12_107_1","first-page":"1","article-title":"The role of cathepsin D in the pathogenesis of tuberculosis. A histochemical study employing unlabeled antibodies and the peroxidase\u2010antiperoxidase complex","volume":"74","author":"Rojas\u2010Espinosa O","year":"1974","journal-title":"Am J Pathol"},{"key":"e_1_2_12_108_1","first-page":"594","article-title":"Prevention of tuberculous cavity formation by desensitization with tuberculin\u2010active peptide","volume":"109","author":"Yamamura Y","year":"1974","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu449"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.201404898"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1906"},{"key":"e_1_2_12_112_1","first-page":"53","volume-title":"A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis","author":"Leong FJ","year":"2011"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2185"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn232"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2013.07.014"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01731-12"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac1029049"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2012.07.028"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku166"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.03.039"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400736"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753944710375820"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.771899"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu203"},{"issue":"10","key":"e_1_2_12_125_1","first-page":"S231","article-title":"Studies on the treatment of tuberculosis undertaken by the British Medical Research Council tuberculosis units, 1946\u20101986, with relevant subsequent publications","volume":"3","author":"Fox W","year":"1999","journal-title":"Int J Tuberc Lung Dis"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-3879(85)90040-6"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.200501"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1086\/346053"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01920-13"},{"key":"e_1_2_12_130_1","first-page":"736","article-title":"Metronidazole has no antibacterial effect in Cornell model murine tuberculosis","volume":"2","author":"Dhillon J","year":"1998","journal-title":"Int J Tuberc Lung Dis"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1121497109"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00196-08"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00753-13"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-6111-1_13"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00887-06"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-9792(08)70035-0"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00912-12"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028082"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2007.12.003"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2013.05.006"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2010.12.006"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010030"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0684.2012.00536.x"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00064-06"}],"container-title":["Immunological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimr.12252","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imr.12252","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imr.12252","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imr.12252","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T21:02:57Z","timestamp":1694638977000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imr.12252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,20]]},"references-count":143,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/imr.12252"],"URL":"https:\/\/doi.org\/10.1111\/imr.12252","archive":["Portico"],"relation":{},"ISSN":["0105-2896","1600-065X"],"issn-type":[{"value":"0105-2896","type":"print"},{"value":"1600-065X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,20]]}}}