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Traditionally, IgA has been thought of as a non\u2010inflammatory antibody that helps to maintain homeostasis in the mucosa. However, in the last decade it has become clear that IgA is a very potent stimulus to initiate pro\u2010inflammatory cellular processes, especially after triggering the IgA Fc receptor (Fc\u03b1\n                    <jats:styled-content style=\"fixed-case\">RI<\/jats:styled-content>\n                    ) on neutrophils. It was furthermore described that Fc\u03b1\n                    <jats:styled-content style=\"fixed-case\">RI<\/jats:styled-content>\n                    acts as a regulator between anti\u2010 and pro\u2010inflammatory responses of IgA. Although neutrophil activation is beneficial in (mucosal) infections, abnormal or excessive IgA immune complexes can induce disproportionate neutrophil migration and in this way initiate a perpetuating neutrophil recruitment and activation loop, which will result in severe tissue damage. Increasing evidence on this process plays a detrimental role in several diseases, including autoimmune IgA blistering diseases, a subtype of rheumatoid arthritis and ulcerative colitis. Inhibiting Fc\u03b1\n                    <jats:styled-content style=\"fixed-case\">RI<\/jats:styled-content>\n                    \u2010mediated activation may dampen inflammation in these patients. This process also opens up the possibility of targeting Fc\u03b1\n                    <jats:styled-content style=\"fixed-case\">RI<\/jats:styled-content>\n                    in antibody immunotherapy of cancer. Thus, interfering with IgA\u2010mediated Fc\u03b1\n                    <jats:styled-content style=\"fixed-case\">RI<\/jats:styled-content>\n                    activation may represent an attractive novel therapeutic strategy for multiple maladies.\n                  <\/jats:p>","DOI":"10.1111\/imr.12337","type":"journal-article","created":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T02:32:28Z","timestamp":1445826748000},"page":"123-138","source":"Crossref","is-referenced-by-count":124,"title":["The era of the immunoglobulin A Fc receptor Fc\u03b1\n                    <scp>RI<\/scp>\n                    ; its function and potential as target in disease"],"prefix":"10.1111","volume":"268","author":[{"given":"Esil","family":"Aleyd","sequence":"first","affiliation":[{"name":"Department of Molecular Cell Biology and Immunology VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke 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