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Yet recent studies report elevated levels of reactive oxygen species and abnormal activation of the unfolded protein response in cells targeted by autoimmunity, implicating cellular stress originating from the target tissue as a contributing factor. A better understanding of this contribution may help to answer important lingering questions in organ\u2010specific autoimmunity, as to what factors initiate disease and what directs its tissue specificity. Vitiligo, an autoimmune disease of the skin, has been the focus of translational research for over 30\u00a0years, and both melanocyte stress and immune mechanisms have been thought to be mutually exclusive explanations for pathogenesis. Chemical\u2010induced vitiligo is a unique clinical presentation that reflects the importance of environmental influences on autoimmunity, provides insight into a new paradigm linking cell stress to the immune response, and serves as a template for other autoimmune diseases. In this review, I will discuss the evidence for cell stress contributions to a number of autoimmune diseases, the questions that remain, and how vitiligo, an underappreciated example of organ\u2010specific autoimmunity, helps to answer them.<\/jats:p>","DOI":"10.1111\/imr.12369","type":"journal-article","created":{"date-parts":[[2015,12,19]],"date-time":"2015-12-19T02:39:36Z","timestamp":1450492776000},"page":"11-25","source":"Crossref","is-referenced-by-count":98,"title":["Cellular stress and innate inflammation in organ\u2010specific autoimmunity: lessons learned from vitiligo"],"prefix":"10.1111","volume":"269","author":[{"given":"John E.","family":"Harris","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Dermatology University of Massachusetts Medical School Worcester MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,19]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Report to 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