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Despite this progress, about 15% and 50% of pediatric and adult cases, respectively, show resistance to treatment or relapse with dismal prognosis, calling for further therapeutic investigations. T\u2010<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> is an heterogeneous disease, which presents intrinsic alterations leading to aberrant expression of transcription factors normally involved in hematopoietic stem\/progenitor cell development and mutations in genes implicated in the regulation of cell cycle progression, apoptosis, and T\u2010cell development. Gene expression profiling allowed the classification of T\u2010<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> into defined molecular subgroups that mostly reflects the stage of their differentiation arrest. So far this knowledge has not translated into novel, targeted therapy. Recent evidence points to the importance of extrinsic signaling cues in controlling the ability of T\u2010<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> to home, survive, and proliferate, thus offering the perspective of new therapeutic options. This review summarizes the present understanding of the interactions between hematopoietic cells and bone marrow\/thymic niches during normal hematopoiesis, describes the main signaling pathways implicated in this dialog, and finally highlights how malignant T cells rely on specific niches to maintain their ability to sustain and propagate leukemia.<\/jats:p>","DOI":"10.1111\/imr.12402","type":"journal-article","created":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T12:58:41Z","timestamp":1460984321000},"page":"156-172","source":"Crossref","is-referenced-by-count":44,"title":["Microenvironmental cues for T\u2010cell acute lymphoblastic leukemia development"],"prefix":"10.1111","volume":"271","author":[{"given":"Diana","family":"Passaro","sequence":"first","affiliation":[{"name":"Hematopoietic Stem Cell Laboratory The Francis Crick Institute Lincoln's Inn Fields Laboratories London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine 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