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Cortical thymic epithelial cells (<jats:styled-content style=\"fixed-case\">cTEC<\/jats:styled-content>s), which structurally and functionally support the thymic cortical microenvironment, originate from endodermal epithelial progenitors that arise in the third pharyngeal pouch. Recent studies have revealed that thymic epithelial progenitors pass through a stage where the cells express <jats:styled-content style=\"fixed-case\">cTEC<\/jats:styled-content>\u2010associated molecules prior to lineage separation into <jats:styled-content style=\"fixed-case\">cTEC<\/jats:styled-content>s and medullary <jats:styled-content style=\"fixed-case\">TEC<\/jats:styled-content>s (<jats:styled-content style=\"fixed-case\">mTEC<\/jats:styled-content>s). Here, we review the molecular signatures of <jats:styled-content style=\"fixed-case\">cTEC<\/jats:styled-content>s and highlight the development and developmental potential of <jats:styled-content style=\"fixed-case\">cTEC<\/jats:styled-content>s.<\/jats:p>","DOI":"10.1111\/imr.12404","type":"journal-article","created":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T12:58:41Z","timestamp":1460984321000},"page":"10-22","source":"Crossref","is-referenced-by-count":58,"title":["Development and developmental potential of cortical thymic epithelial cells"],"prefix":"10.1111","volume":"271","author":[{"given":"Izumi","family":"Ohigashi","sequence":"first","affiliation":[{"name":"Division of Experimental Immunology Institute for Genome Research University of Tokushima Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Kozai","sequence":"additional","affiliation":[{"name":"Division of Experimental Immunology Institute for Genome Research 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