{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:46:22Z","timestamp":1761489982209},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T00:00:00Z","timestamp":1460937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunological Reviews"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Thymus transplants were never used to correct T\u2010cell intrinsic deficiencies, as it is generally believed that thymocytes have short intrinsic lifespans. This notion is based on multiple thymus transplantation experiments, where it was shown that thymus\u2010resident cells were rapidly replaced by progenitors migrating from the bone marrow (<jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content>). This substitution occurs even when bone marrow precursors are unable to generate T cells, as in Rag1\/2<jats:sup>\u2212<\/jats:sup> or severe combined immunodeficiency (<jats:styled-content style=\"fixed-case\">SCID<\/jats:styled-content>)\u2010deficient mice. In contrast, two groups reported that neonatal thymi transplanted into mice that cannot respond to <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20107 harbor populations with extensive capacity to self\u2010renew, which maintain continuous thymocyte generation for several months after surgery. The consequences of this self\u2010renewal capacity differed in these two laboratories. We found that these thymus transplants rapidly reconstitute the full diversity of peripheral T\u2010cell repertoires 1\u00a0month after surgery, the earliest time point studied. Moreover, transplantation experiments performed across major histocompatibility barriers show that allogeneic\u2010transplanted thymi are not rejected, and allogeneic cells do not induce graft\u2010versus\u2010host disease, both syngeneic and allogeneic transplants inducing rapid protection from infection. These results indicate a potential use of neonatal thymus transplants to correct T\u2010cell intrinsic deficiencies. The other group observed that continuous thymocyte renewal from <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> precursors was fundamental to prevent tumor development. In the absence of this input, thymocytes from the transplanted thymus generated tumors with all the characteristics of T\u2010cell acute lymphoblastic leukemia (T\u2010<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>). Moreover, they suggested that the absence of <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> competition was responsible for the T\u2010<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>s developing in X\u2010linked severe combined immunodeficiency (<jats:styled-content style=\"fixed-case\">SCID<\/jats:styled-content>)\u2010X1 patients, deficient in the expression of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>2\u2010R\u03b3<jats:sub>c<\/jats:sub>. These patients were treated with autologous <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34<jats:sup>+<\/jats:sup> cells transfected with virus vectors expressing \u03b3<jats:sub>c<\/jats:sub> in the absence of myeloablation. We here review the potential therapeutic impact of thymus transplantation and compare the results of these two laboratories aiming to find an answer to the \u2018Dr Jekill versus Mr. Hyde\u2019 status of thymus transplantation experiments.<\/jats:p>","DOI":"10.1111\/imr.12408","type":"journal-article","created":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T12:58:41Z","timestamp":1460984321000},"page":"173-184","source":"Crossref","is-referenced-by-count":13,"title":["Thymocytes self\u2010renewal: a major hope or a major threat?"],"prefix":"10.1111","volume":"271","author":[{"given":"Laetitia","family":"Peaudecerf","sequence":"first","affiliation":[{"name":"INSERM Unit 1020, Faculty of Medicine Descartes Paris V Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Krenn","sequence":"additional","affiliation":[{"name":"INSERM Unit 1020, Faculty of Medicine Descartes Paris V Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Institut Pasteur Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Vasseur","sequence":"additional","affiliation":[{"name":"INSERM Unit 1020, Faculty of Medicine Descartes Paris V Paris France"},{"name":"Institut Pasteur Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedita","family":"Rocha","sequence":"additional","affiliation":[{"name":"INSERM Unit 1020, Faculty of Medicine Descartes Paris V Paris France"},{"name":"Institut Pasteur Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,18]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2015.04.002"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2009.08.001"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-008-0139-y"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1997.tb00975.x"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.2217\/imt.10.36"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2008.03.001"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-06-292490"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-048652"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.11.1839"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.175.4.1067"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80317-9"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20120845"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20120846"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13317"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI35700"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1088547"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI35798"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1293"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2010.47"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073098"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02284"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.5.591"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(98)80249-5"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11599"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12513-5"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-010-8191-9"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1233151"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007280"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20042524"},{"key":"e_1_2_13_31_1","first-page":"853","article-title":"The oncogenic LIM protein Rbtn2 causes thymic developmental aberrations that precede malignancy in transgenic mice","volume":"11","author":"Larson RC","year":"1995","journal-title":"Oncogene"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2005.09.010"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1404588"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/14653240510027118"}],"container-title":["Immunological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimr.12408","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imr.12408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T21:28:40Z","timestamp":1694640520000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imr.12408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,18]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/imr.12408"],"URL":"https:\/\/doi.org\/10.1111\/imr.12408","archive":["Portico"],"relation":{},"ISSN":["0105-2896","1600-065X"],"issn-type":[{"value":"0105-2896","type":"print"},{"value":"1600-065X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,18]]}}}