{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:08:16Z","timestamp":1790374096463,"version":"4.1.0"},"reference-count":162,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T00:00:00Z","timestamp":1485734400000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1068333"],"award-info":[{"award-number":["OPP1068333"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1151372."],"award-info":[{"award-number":["OPP1151372."]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunological Reviews"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Development of an efficacious <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u20101 vaccine is a major priority for improving human health worldwide. Vaccine\u2010mediated protection against human pathogens can be achieved through elicitation of protective innate, humoral, and cellular responses. Identification of specific immune responses responsible for pathogen protection enables vaccine development and provides insights into host defenses against pathogens and the immunological mechanisms that most effectively fight infection. Defining immunological correlates of transmission risk in preclinical and clinical <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u20101 vaccine trials has moved the <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u20101 vaccine development field forward and directed new candidate vaccine development. Immune correlate studies are providing novel hypotheses about immunological mechanisms that may be responsible for preventing <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u20101 acquisition. Recent results from <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u20101 immune correlates work has demonstrated that there are multiple types of immune responses that together, comprise an immune correlate\u2014thus implicating polyfunctional immune control of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u20101 transmission. An in depth understanding of these complex immunological mechanisms of protection against <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u20101 will accelerate the development of an efficacious <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u20101 vaccine.<\/jats:p>","DOI":"10.1111\/imr.12514","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T06:44:24Z","timestamp":1485758664000},"page":"245-261","source":"Crossref","is-referenced-by-count":112,"title":["Complex immune correlates of protection in <scp>HIV<\/scp>\u20101 vaccine efficacy trials"],"prefix":"10.1111","volume":"275","author":[{"given":"Georgia D.","family":"Tomaras","sequence":"first","affiliation":[{"name":"Departments of Surgery, Immunology, Molecular Genetics and Microbiology Duke Human Vaccine Institute  Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley A.","family":"Plotkin","sequence":"additional","affiliation":[{"name":"Vaxconsult  Doylestown PA USA"},{"name":"University of Pennsylvania School of Medicine  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00131-10"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis238"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit048"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/589862"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032414-112315"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.05.049"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/314845"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/170.3.592"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.05313-11"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(05)80379-4"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/314578"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/147.6.1100"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1006\/biol.1994.1062"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1201-9712(07)60016-2"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.04.068"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/162.5.1036"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1086\/513967"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/106.2.170"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/171.6.1690"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199201000-00006"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199510000-00011"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu279"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400022610"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3182367662"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-10-18"},{"key":"e_1_2_10_27_1","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1542\/peds.56.3.380","article-title":"Long\u2010term follow\u2010up for immunity after monovalent or combined live measles, mumps, and rubella virus vaccines","volume":"56","author":"Weibel RE","year":"1975","journal-title":"Pediatrics"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/162.6.1291"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1972.21.214"},{"key":"e_1_2_10_30_1","first-page":"307","article-title":"The minimum protective level of antibodies in smallpox","volume":"52","author":"Sarkar JK","year":"1975","journal-title":"Bull World Health Organ"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2002.66.533"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir970"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv164"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1086\/605611"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00230-14"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1603734"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5458.1664"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2010.02.029"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2129"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2447"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414216"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah6157"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.12.073"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1102287"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001685"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208394"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60721-8"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.09.073"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.15.8869"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1237874"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908492"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines2010015"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1086\/508748"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1086\/428404"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61591-3"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)70020-9"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61592-5"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(11)70098-6"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0b013e32833d2d2b"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis342"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310566"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1086\/428405"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.10.6596"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1086\/654816"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00138-10"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001122"},{"key":"e_1_2_10_67_1","volume-title":"HVTN 505 Breakthrough Sequences Showed HIV Vaccine\u2010Associated Differences in Env\u2010gp120","author":"Rolland M","year":"2015"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2316"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiq114"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002002"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit322"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1113425"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007730"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087572"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1301456110"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075665"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.10.027"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2012.0103"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053629"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12561-016-9177-5"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911796106"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1566"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002686"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3715"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aag1276"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11519"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.11.011"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02737-12"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01023-12"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005817"},{"issue":"3","key":"e_1_2_10_91_1","first-page":"S277","article-title":"Development of bivalent rgp120 vaccines to prevent HIV type 1 infection","volume":"14","author":"Berman PW","year":"1998","journal-title":"AIDS Res Hum Retroviruses"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3014647"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00718-12"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03635-14"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007736"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-12-294"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040320"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis033"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.09.011"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.14.6558-6565.2001"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.04.050"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00171-11"},{"key":"e_1_2_10_103_1","first-page":"423","article-title":"Suppression by IgA of IgG\u2010mediated phagocytosis by human polymorphonuclear leucocytes","volume":"34","author":"Wilton JM","year":"1978","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_10_104_1","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.4049\/jimmunol.130.6.2882","article-title":"IgA blocks IgM and IgG\u2010initiated immune lysis by separate molecular mechanisms","volume":"130","author":"Griffiss JM","year":"1983","journal-title":"J Immunol"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199812)28:12<4001::AID-IMMU4001>3.0.CO;2-1"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910270208"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02363-15"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00156-14"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00290.x"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328360eac6"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12977-014-0078-8"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3187"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03765-13"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aab4005"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI75539"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0802203105"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3471"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000890"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofu056"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1070441"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01705-14"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.3.4.S161"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.02.002"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005742"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001033"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-05-431361"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01164-14"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2015.60"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1208972109"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10369"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI75429"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4105"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19970228)16:4<385::AID-SIM380>3.0.CO;2-3"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.51"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.145"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1250672"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1413550111"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.01.031"},{"key":"e_1_2_10_139_1","volume-title":"Met\u2010Analysis of Ad5\u2010Vector HIV Vaccine Trials to Assess the Vaccine Effect on HIV Acquisition","author":"Gilbert P","year":"2013"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146387"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(16)30087-X"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2016.02.010"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aab3886"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.09.061"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12692"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI80561"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.01.013"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1086\/522232"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa066092"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(12)70088-9"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283629037"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1202614"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011205"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105243"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1600693"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60312-2"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0020298"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1193748"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aab1253"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2016.01.007"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/kxm028"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1541-0420.2007.00845.x"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2014.10.022"}],"container-title":["Immunological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimr.12514","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imr.12514","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T17:31:12Z","timestamp":1694626272000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imr.12514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":162,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1111\/imr.12514"],"URL":"https:\/\/doi.org\/10.1111\/imr.12514","archive":["Portico"],"relation":{},"ISSN":["0105-2896","1600-065X"],"issn-type":[{"value":"0105-2896","type":"print"},{"value":"1600-065X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]}}}