{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T06:06:19Z","timestamp":1792303579635,"version":"4.4.0"},"reference-count":231,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,16]],"date-time":"2017-12-16T00:00:00Z","timestamp":1513382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunological Reviews"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Summary<\/jats:title>\n \n Initially described as an interferon (\n IFN<\/jats:styled-content>\n )\u03b3\u2010inducing factor,\n interleukin (IL)\u201018<\/jats:styled-content>\n is indeed involved in Th1 and\n NK<\/jats:styled-content>\n cell activation, but also in Th2,\n IL<\/jats:styled-content>\n \u201017\u2010producing \u03b3\u03b4 T cells and macrophage activation.\n IL<\/jats:styled-content>\n \u201018, a member of the\n IL<\/jats:styled-content>\n \u20101 family, is similar to\n IL<\/jats:styled-content>\n \u20101\u03b2 for being processed by caspase 1 to an 18\u00a0kDa\u2010biologically active mature form.\n IL<\/jats:styled-content>\n \u201018 binds to its specific receptor (\n IL<\/jats:styled-content>\n \u201018R\u03b1, also known as\n IL<\/jats:styled-content>\n \u20101R7) forming a low affinity ligand chain. This is followed by recruitment of the\n IL<\/jats:styled-content>\n \u201018R\u03b2 chain.\n IL<\/jats:styled-content>\n \u201018 then uses the same signaling pathway as\n IL<\/jats:styled-content>\n \u20101 to activate\n NF<\/jats:styled-content>\n \u2010\n kB<\/jats:styled-content>\n and induce inflammatory mediators such as adhesion molecules, chemokines and Fas ligand.\n IL<\/jats:styled-content>\n \u201018 also binds to the circulating high affinity\n IL<\/jats:styled-content>\n \u201018 binding protein (\n BP<\/jats:styled-content>\n ), such as only unbound free\n IL<\/jats:styled-content>\n \u201018 is active.\n IL<\/jats:styled-content>\n \u201018R\u03b1 may also bind\n IL<\/jats:styled-content>\n \u201037, another member of the\n IL<\/jats:styled-content>\n \u20101 family, but in association with the negative signaling chain termed\n IL<\/jats:styled-content>\n \u20101R8, which transduces an anti\u2010inflammatory signal.\n IL<\/jats:styled-content>\n \u201018\n BP<\/jats:styled-content>\n also binds\n IL<\/jats:styled-content>\n \u201037 and this acts as a sink for the anti\u2010inflammatory properties of\n IL<\/jats:styled-content>\n \u201037. There is now ample evidence for a role of\n IL<\/jats:styled-content>\n \u201018 in various infectious, metabolic or inflammatory diseases such as influenza virus infection, atheroma, myocardial infarction, chronic obstructive pulmonary disease, or Crohn's disease. However,\n IL<\/jats:styled-content>\n \u201018 plays a very specific role in the pathogenesis of hemophagocytic syndromes (\n HS<\/jats:styled-content>\n ) also termed Macrophage Activation Syndrome. In children affected by\n NLRC<\/jats:styled-content>\n 4 gain\u2010of\u2010function mutations,\n IL<\/jats:styled-content>\n \u201018 circulates in the range of tens of nanograms\/mL.\n HS<\/jats:styled-content>\n is treated with the\n IL<\/jats:styled-content>\n \u20101 Receptor antagonist (anakinra) but also specifically with\n IL<\/jats:styled-content>\n \u201018\n BP<\/jats:styled-content>\n . Systemic juvenile idiopathic arthritis or adult\u2010onset Still's disease are also characterized by high serum\n IL<\/jats:styled-content>\n \u201018 concentrations and are treated by\n IL<\/jats:styled-content>\n \u201018BP.\n <\/jats:p>","DOI":"10.1111\/imr.12616","type":"journal-article","created":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T03:53:15Z","timestamp":1513569195000},"page":"138-153","source":"Crossref","is-referenced-by-count":572,"title":["Interleukin\u201018: Biological properties and role in disease pathogenesis"],"prefix":"10.1111","volume":"281","author":[{"given":"Gilles","family":"Kaplanski","sequence":"first","affiliation":[{"name":"Assistance Publique\u2010H\u00f4pitaux de Marseille Centre Hospitalier Universitaire Conception Service de M\u00e9decine Interne et Immunologie Clinique Aix\u2010Marseille Universit\u00e9 Marseille France"},{"name":"Vascular Research Center Marseille Facult\u00e9 de Pharmacie Aix\u2010Marseille Universit\u00e9 INSERM UMR_S1076 Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.61.1.64-70.1993"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/378088a0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70518-X"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.1999.0837"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.423"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00289"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2013.10.014"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.63.6.658"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5297.206"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/386619a0"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12287"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80111-9"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202121"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.42.26595"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2010.05.004"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.12.8315"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M802814200"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.11.6568"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.41.25737"},{"key":"e_1_2_8_21_1","doi-asserted-by":"crossref","first-page":"5041","DOI":"10.4049\/jimmunol.162.9.5041","article-title":"Cutting edge: Generation of IL\u201018 receptor\u2010deficient mice: Evidence for IL\u20101 receptor\u2010related protein as an essential IL\u201018 binding receptor","volume":"162","author":"Hoshino K","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/08830189809043005"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402800101"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.3.1307"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2014.02.015"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.72.2.401"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.212519099"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1944"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0607917103"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.004184"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3103"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1424626112"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1111982108"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020506300324"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.157.9.3967"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201142173"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.12.2103"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.162.9.5070"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/77811"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.24.13962"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103212"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.08.001"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40099"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1515793113"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61029"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.64.4.519"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M103574200"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.2.734"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1379"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780351"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22705"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0528.2002.017418.x"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00393.2001"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80013-8"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.3.1190"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2001.0914"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-05-1980"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.4.2100"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.2064"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.262663399"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020600230977"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.2017019158"},{"key":"e_1_2_8_63_1","first-page":"504","article-title":"Interleukin\u201018 and its binding protein in patients with inflammatory bowel disease during remission and exacerbation","volume":"9","author":"Naftali T","year":"2007","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20272"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.163.1.143"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.162.11.6829"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3089"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2003.03097.x"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2001.281.4.R1264"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.28021"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.29579"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.6.812"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.10.072"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.197822"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.231473998"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20160462"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.285"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MIB.0000182868.67025.b9"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2008.03.016"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.03.003"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.02.012"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2017.01.001"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.10.048"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.04.022"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.01.026"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.06.014"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00181"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.13"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.03.010"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.11.041"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303329"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.31"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.2174\/13894501113146660229"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66378-7"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.169404"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e32833bf6dc"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000163843.70369.12"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.149484"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2005.07.008"},{"key":"e_1_2_8_100_1","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1016\/j.numecd.2008.10.002","article-title":"IL\u201018 gene polymorphism and metabolic syndrome","volume":"19","author":"Presta I","year":"2009","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-07-0206"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.01897"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1381\/096089206777346763"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1415"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611523104"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-1095"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2008.109"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-9-11"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.05.005"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150018"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08938"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011022"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc3901.096721"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1161\/hh1901.098735"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1161\/hh0202.105292"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(03)00343-2"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs226"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000020546.30940.92"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000099509.76044.A2"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.11.013"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.12.026"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.84.6.668"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.10.010"},{"key":"e_1_2_8_124_1","first-page":"87","article-title":"Interleukin\u201018 in patients with congestive heart failure: Induction of atrial natriuretic peptide gene expression","volume":"108","author":"Seta Y","year":"2000","journal-title":"Res Commun Mol Pathol Pharmacol"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-2426fje"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(03)00339-0"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M808824200"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0908924106"},{"key":"e_1_2_8_129_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M411787200"},{"key":"e_1_2_8_130_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01179.2004"},{"key":"e_1_2_8_131_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.041611398"},{"key":"e_1_2_8_132_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00795.2013"},{"key":"e_1_2_8_133_1","doi-asserted-by":"publisher","DOI":"10.1177\/0267659108101511"},{"key":"e_1_2_8_134_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01285.2008"},{"key":"e_1_2_8_135_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200905-0652OC"},{"key":"e_1_2_8_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2008.67"},{"key":"e_1_2_8_137_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.112275"},{"key":"e_1_2_8_138_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00033811"},{"key":"e_1_2_8_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2013.09.004"},{"key":"e_1_2_8_140_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.3.9805026"},{"key":"e_1_2_8_141_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054623"},{"key":"e_1_2_8_142_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032158"},{"key":"e_1_2_8_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri803"},{"key":"e_1_2_8_144_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.3.1948"},{"key":"e_1_2_8_145_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00019207"},{"key":"e_1_2_8_146_1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3109\/15412555.2012.670330","article-title":"Increased expression of interleukin\u201018 and its receptor in peripheral blood of patients with chronic obstructive pulmonary disease","volume":"9","author":"Wang J","year":"2012","journal-title":"COPD"},{"key":"e_1_2_8_147_1","first-page":"2771","article-title":"Cigarette smoke selectively enhances viral PAMP\u2010 and virus\u2010induced pulmonary innate immune and remodeling responses in mice","volume":"118","author":"Kang MJ","year":"2008","journal-title":"J Clin Invest"},{"key":"e_1_2_8_148_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2012-0173OC"},{"key":"e_1_2_8_149_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200603-316OC"},{"key":"e_1_2_8_150_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201108-1545OC"},{"key":"e_1_2_8_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2017.01.014"},{"key":"e_1_2_8_152_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0519-RA"},{"key":"e_1_2_8_153_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201201-0003OC"},{"key":"e_1_2_8_154_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-012-1409-3"},{"key":"e_1_2_8_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.02.005"},{"key":"e_1_2_8_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.02.006"},{"key":"e_1_2_8_157_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.19596-0"},{"key":"e_1_2_8_158_1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1365-2567.2004.02000.x","article-title":"Enhanced viral clearance in interleukin\u201018 gene\u2010deficient mice after pulmonary infection with influenza A virus","volume":"114","author":"Sluijs KF","year":"2005","journal-title":"Immunology"},{"key":"e_1_2_8_159_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636766"},{"key":"e_1_2_8_160_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003392"},{"key":"e_1_2_8_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15595-5"},{"key":"e_1_2_8_162_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117846"},{"key":"e_1_2_8_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep10942"},{"key":"e_1_2_8_164_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20255"},{"key":"e_1_2_8_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/445267a"},{"key":"e_1_2_8_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05495"},{"key":"e_1_2_8_167_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep27912"},{"key":"e_1_2_8_168_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.4MR0616-288R"},{"key":"e_1_2_8_169_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.36"},{"key":"e_1_2_8_170_1","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-200210000-00002"},{"key":"e_1_2_8_171_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.5.2644"},{"key":"e_1_2_8_172_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201308-1535OC"},{"key":"e_1_2_8_173_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/11.3.471"},{"key":"e_1_2_8_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2014.02.017"},{"key":"e_1_2_8_175_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000080492.81509.29"},{"key":"e_1_2_8_176_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.5.2536"},{"key":"e_1_2_8_177_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.12.6896-6903.2002"},{"key":"e_1_2_8_178_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-02-412726"},{"key":"e_1_2_8_179_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10558"},{"key":"e_1_2_8_180_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13683"},{"key":"e_1_2_8_181_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-041610-134208"},{"key":"e_1_2_8_182_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000127779.24232.15"},{"key":"e_1_2_8_183_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2803"},{"key":"e_1_2_8_184_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2015.179"},{"key":"e_1_2_8_185_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-10-3413"},{"key":"e_1_2_8_186_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00448"},{"key":"e_1_2_8_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.09.010"},{"key":"e_1_2_8_188_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI43157"},{"key":"e_1_2_8_189_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.33496"},{"key":"e_1_2_8_190_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501035"},{"key":"e_1_2_8_191_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V78.11.2918.2918"},{"key":"e_1_2_8_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2016.07.023"},{"key":"e_1_2_8_193_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37958"},{"key":"e_1_2_8_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.11.030"},{"key":"e_1_2_8_195_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20268"},{"key":"e_1_2_8_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2015.06.005"},{"key":"e_1_2_8_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2013.09.007"},{"key":"e_1_2_8_198_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008663"},{"key":"e_1_2_8_199_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00239"},{"key":"e_1_2_8_200_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-12-684399"},{"key":"e_1_2_8_201_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3066"},{"key":"e_1_2_8_202_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.763979"},{"key":"e_1_2_8_203_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.10.022"},{"key":"e_1_2_8_204_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210324"},{"key":"e_1_2_8_205_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2012.07.022"},{"key":"e_1_2_8_206_1","first-page":"1133","article-title":"Occult macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis","volume":"34","author":"Behrens EM","year":"2007","journal-title":"J Rheumatol"},{"key":"e_1_2_8_207_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050473"},{"key":"e_1_2_8_208_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22981"},{"key":"e_1_2_8_209_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23437"},{"key":"e_1_2_8_210_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.11.025"},{"key":"e_1_2_8_211_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780340912"},{"key":"e_1_2_8_212_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1112802"},{"key":"e_1_2_8_213_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200103)44:3<550::AID-ANR103>3.0.CO;2-5"},{"key":"e_1_2_8_214_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10389"},{"key":"e_1_2_8_215_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu524"},{"key":"e_1_2_8_216_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22194"},{"key":"e_1_2_8_217_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kew300"},{"key":"e_1_2_8_218_1","doi-asserted-by":"crossref","first-page":"4214","DOI":"10.1038\/s41598-017-04086-w","article-title":"Upregulation of circulating microRNA\u2010134 in adult\u2010onset Still's disease and its use as potential biomarker","volume":"7","author":"Liao TL","year":"2017","journal-title":"Sci Rep"},{"key":"e_1_2_8_219_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22644"},{"key":"e_1_2_8_220_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34604"},{"key":"e_1_2_8_221_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38359"},{"key":"e_1_2_8_222_1","doi-asserted-by":"crossref","first-page":"4238","DOI":"10.4049\/jimmunol.140.12.4238","article-title":"IL\u20101 induces IL\u20101. III. Specific inhibition of IL\u20101 production by IFN\u2010gamma","volume":"140","author":"Ghezzi P","year":"1988","journal-title":"J Immunol"},{"key":"e_1_2_8_223_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.05.003"},{"key":"e_1_2_8_224_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2003.110"},{"key":"e_1_2_8_225_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1453"},{"key":"e_1_2_8_226_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.111500"},{"key":"e_1_2_8_227_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38793"},{"key":"e_1_2_8_228_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39295"},{"key":"e_1_2_8_229_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39933"},{"key":"e_1_2_8_230_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24750"},{"key":"e_1_2_8_231_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200104)44:4<884::AID-ANR145>3.0.CO;2-4"},{"key":"e_1_2_8_232_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23088"}],"container-title":["Immunological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimr.12616","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imr.12616","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T20:06:36Z","timestamp":1694462796000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imr.12616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,16]]},"references-count":231,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1111\/imr.12616"],"URL":"https:\/\/doi.org\/10.1111\/imr.12616","archive":["Portico"],"relation":{},"ISSN":["0105-2896","1600-065X"],"issn-type":[{"value":"0105-2896","type":"print"},{"value":"1600-065X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,16]]}}}