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Although the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101 molecules are traditionally considered to be classical proinflammatory cytokines, their functions are not restricted to inflammation, and they have also been shown to play a key role in a wide range of additional physiological and pathological functions, including learning modulation, sleep, pregnancy, depression, appetite, hematopoiesis, metabolism, and many others. Since their effect as cytokines and regulators of inflammation is so pleiotropic, any shift of the biological balance between agonistic and antagonistic signals has the potential to cause disease. Here, we consider the genetic influence of interleukin\u20101 gene polymorphism in the context of susceptibility to human diseases. We review known single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>) of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101 genes linked to human diseases, and suggest how exploring biological effects of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101 gene cluster polymorphism may lead to new directions in understanding and diagnostic of disease and effective treatment.<\/jats:p>","DOI":"10.1111\/imr.12620","type":"journal-article","created":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T08:53:15Z","timestamp":1513587195000},"page":"40-56","source":"Crossref","is-referenced-by-count":75,"title":["Interleukin 1 gene polymorphism and susceptibility to disease"],"prefix":"10.1111","volume":"281","author":[{"given":"Khaled","family":"Khazim","sequence":"first","affiliation":[{"name":"Faculty of Medicine in the Galilee Bar Ilan University  Safed Israel"},{"name":"Department of Nephrology and Hypertension Galilee Medical Center  Nahariya Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etti Ester","family":"Azulay","sequence":"additional","affiliation":[{"name":"Faculty of Medicine in the Galilee Bar Ilan University  Safed Israel"},{"name":"Research Institute Galilee Medical Center  Nahariya Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Batya","family":"Kristal","sequence":"additional","affiliation":[{"name":"Faculty of Medicine in the Galilee Bar Ilan University  Safed Israel"},{"name":"Department of Nephrology and Hypertension Galilee Medical Center  Nahariya Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6933-9385","authenticated-orcid":false,"given":"Idan","family":"Cohen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine in the Galilee Bar Ilan University  Safed Israel"},{"name":"Research Institute Galilee Medical Center  Nahariya Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,16]]},"reference":[{"key":"e_1_2_20_2_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781420005325"},{"key":"e_1_2_20_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-014-0780-7"},{"key":"e_1_2_20_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132612"},{"key":"e_1_2_20_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00701.x"},{"key":"e_1_2_20_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201084"},{"key":"e_1_2_20_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.11.010"},{"key":"e_1_2_20_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-146720"},{"key":"e_1_2_20_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.06.033"},{"key":"e_1_2_20_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-273417"},{"key":"e_1_2_20_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0915018107"},{"key":"e_1_2_20_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2016.11.002"},{"key":"e_1_2_20_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601342"},{"key":"e_1_2_20_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2873"},{"key":"e_1_2_20_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/672395"},{"key":"e_1_2_20_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102048"},{"key":"e_1_2_20_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12174"},{"key":"e_1_2_20_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00123"},{"key":"e_1_2_20_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.06.003"},{"key":"e_1_2_20_20_1","doi-asserted-by":"crossref","first-page":"7081","DOI":"10.1016\/S0021-9258(20)89612-4","article-title":"Structure\u2010function mapping of interleukin 1 precursors. 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