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Mast cells act as a \u201cpower house\u201d by releasing algogenic and pruritogenic mediators, which initiate a reciprocal communication with specific nociceptors on sensory nerve fibers. Consequently, nerve fibers release inflammatory and vasoactive neuropeptides, which in turn activate mast cells in a feedback mechanism, thus promoting a vicious cycle of mast cell and nociceptor activation leading to neurogenic inflammation and pain\/pruritus. Mechanisms underlying mast cell differentiation, activation, and intercellular interactions with inflammatory, vascular, and neural systems are deeply influenced by their microenvironment, imparting enormous heterogeneity and complexity in understanding their contribution to pain and pruritus. Neurogenic inflammation is central to both pain and pruritus, but specific mediators released by mast cells to promote this process may vary depending upon their location, stimuli, underlying pathology, gender, and species. Therefore, in this review, we present the contribution of mast cells in pathological conditions, including distressing pruritus exacerbated by psychologic stress and experienced by the majority of patients with psoriasis and atopic dermatitis and in different pain syndromes due to mastocytosis, sickle cell disease, and cancer.<\/jats:p>","DOI":"10.1111\/imr.12622","type":"journal-article","created":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T12:30:23Z","timestamp":1518438623000},"page":"168-187","source":"Crossref","is-referenced-by-count":266,"title":["Mast cell\u2010neural interactions contribute to pain and itch"],"prefix":"10.1111","volume":"282","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9381-9979","authenticated-orcid":false,"given":"Kalpna","family":"Gupta","sequence":"first","affiliation":[{"name":"Vascular Biology Center Division of Hematology\/Oncology\/Transplantation Department of Medicine University of Minnesota Minneapolis MN 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