{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:30:00Z","timestamp":1790267400347,"version":"4.1.0"},"reference-count":190,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T00:00:00Z","timestamp":1523923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030_146140"],"award-info":[{"award-number":["310030_146140"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunological Reviews"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The induction of long\u2010lived populations of memory T cells residing in peripheral tissues is of considerable interest for T cell\u2010based vaccines, as they can execute immediate effector functions and thus provide protection in case of pathogen encounter at mucosal and barrier sites. Cytomegalovirus (<jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>)\u2010based vaccines support the induction and accumulation of a large population of effector memory <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8 T cells in peripheral tissues, in a process called memory inflation. Tissue\u2010resident memory (T<jats:sub>RM<\/jats:sub>) T cells, induced by various infections and vaccination regimens, constitute another subset of memory cells that take long\u2010term residence in peripheral tissues. Both memory T cell subsets have evoked substantial interest in exploitation for vaccine purposes. However, a direct comparison between these two peripheral tissue\u2010localizing memory T cell subsets with respect to their short\u2010 and long\u2010term ability to provide protection against heterologous challenge is pending. Here, we discuss communalities and differences between T<jats:sub>RM<\/jats:sub> and inflationary <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8 T cells with respect to their development, maintenance, function, and protective capacity. In addition, we discuss differences and similarities between the transcriptional profiles of T<jats:sub>RM<\/jats:sub> and inflationary T cells, supporting the notion that they are distinct memory T cell populations.<\/jats:p>","DOI":"10.1111\/imr.12649","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T15:21:39Z","timestamp":1523978499000},"page":"161-175","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Memory <scp>CD<\/scp>8 T cell inflation vs tissue\u2010resident memory T cells: Same patrollers, same controllers?"],"prefix":"10.1111","volume":"283","author":[{"given":"Suzanne P. M.","family":"Welten","sequence":"first","affiliation":[{"name":"Institute of Microbiology Department of Biology ETH Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana","family":"Sandu","sequence":"additional","affiliation":[{"name":"Institute of Microbiology Department of Biology ETH Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas S.","family":"Baumann","sequence":"additional","affiliation":[{"name":"Institute of Microbiology Department of Biology ETH Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2079-2354","authenticated-orcid":false,"given":"Annette","family":"Oxenius","sequence":"additional","affiliation":[{"name":"Institute of Microbiology Department of Biology ETH Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2010.00926.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3307"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12205"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3031"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2015.09.004"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081242"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.07.010"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.10.010"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002042"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1159806"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1090148"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.06.021"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080526"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.05.014"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.1.242"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199901)29:01<291::AID-IMMU291>3.0.CO;2-K"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200011)30:11<3207::AID-IMMU3207>3.0.CO;2-L"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500993"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.2.795"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.8.3950"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-09-3581"},{"key":"e_1_2_8_23_1","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.4049\/jimmunol.140.5.1401","article-title":"Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA\u20103, CD2, and LFA\u20101) and three other molecules (UCHL1, CDw29, and Pgp\u20101) and have enhanced IFN\u2010gamma production","volume":"140","author":"Sanders ME","year":"1988","journal-title":"J Immunol"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002145"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.08.002"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1268"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.11.012"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni802"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.09.017"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.2.883"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.09.016"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1009"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020369"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020033"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.11.5566"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.2.705"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.7.4677"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1718"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.10.1575"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.11.007"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10851"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1058867"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/44385"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.22.012703.104702"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.9.1407"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)01139-X"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni889"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.8.4875"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.4.2079"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10339"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201343519"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1107200108"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.09.076"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.09.082"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.9.5837"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20162115"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.7.4355"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.09.020"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.118"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.85832"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102243"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.38"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00352"},{"key":"e_1_2_8_64_1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3389\/fimmu.2017.00335","article-title":"CD103+ CD8 T cells in the toxoplasma\u2010infected brain exhibit a tissue\u2010resident memory transcriptional profile","volume":"8","author":"Landrith TA","year":"2017","journal-title":"Front Immunol"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201305"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aam6346"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-396548-6.00008-1"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201041377"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.10.1631"},{"key":"e_1_2_8_70_1","doi-asserted-by":"crossref","first-page":"6641","DOI":"10.4049\/jimmunol.162.11.6641","article-title":"Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)\u2010deficient mice","volume":"162","author":"Schon MP","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2029"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.08.078"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.03.031"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2744"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02493-10"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aaj1996"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3589"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.02.048"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad2035"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.11.008"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3860"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms16073"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2015.3"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aam6970"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2745"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1202288109"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20151855"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.07.037"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20160938"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1322292111"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1502337"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20151916"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aag2031"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201646722"},{"key":"e_1_2_8_95_1","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.4049\/jimmunol.1701272","article-title":"The Chemokine Receptor CXCR3 Promotes CD8+ T Cell Accumulation in Uninfected Salivary Glands but Is Not Necessary after Murine Cytomegalovirus Infection","volume":"2003","author":"Caldeira\u2010Dantas S","year":"2018","journal-title":"J Immunol"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.124"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21379"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13346"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1208927109"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601367"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2016.11.011"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12110"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1254803"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20142101"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1254536"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2568"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.08.011"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01686-16"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3775"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2011.11.005"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.1.450"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.4.2022"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050882"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.07.017"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42758"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004251"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201545650"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2010.0140"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005895"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006072"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1203173"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014646"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002313"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.031815-0"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20160758"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-09-381574"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402757"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02003-14"},{"key":"e_1_2_8_129_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004233"},{"key":"e_1_2_8_130_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200637023"},{"key":"e_1_2_8_131_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501083"},{"key":"e_1_2_8_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2079"},{"key":"e_1_2_8_133_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201141575"},{"key":"e_1_2_8_134_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900227"},{"key":"e_1_2_8_135_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.4.2195"},{"key":"e_1_2_8_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200940256"},{"key":"e_1_2_8_137_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03305-12"},{"key":"e_1_2_8_138_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425534"},{"key":"e_1_2_8_139_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01248-06"},{"key":"e_1_2_8_140_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.6.1047"},{"key":"e_1_2_8_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10003"},{"key":"e_1_2_8_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1935"},{"key":"e_1_2_8_143_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.5.2255-2264.2004"},{"key":"e_1_2_8_144_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001275"},{"key":"e_1_2_8_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.03.029"},{"key":"e_1_2_8_146_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-14-0044"},{"key":"e_1_2_8_147_1","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0b013e3182585d50"},{"key":"e_1_2_8_148_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201343946"},{"key":"e_1_2_8_149_1","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.000339"},{"key":"e_1_2_8_150_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1602115"},{"key":"e_1_2_8_151_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1310215110"},{"key":"e_1_2_8_152_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03177-15"},{"key":"e_1_2_8_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.06.068"},{"key":"e_1_2_8_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.02.043"},{"key":"e_1_2_8_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep21674"},{"key":"e_1_2_8_156_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01669-12"},{"key":"e_1_2_8_157_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002295"},{"key":"e_1_2_8_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.10.034"},{"key":"e_1_2_8_159_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202665"},{"key":"e_1_2_8_160_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0801117"},{"key":"e_1_2_8_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.10.007"},{"key":"e_1_2_8_162_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.3.1439"},{"key":"e_1_2_8_163_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003122"},{"key":"e_1_2_8_164_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12779"},{"key":"e_1_2_8_165_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1201453109"},{"key":"e_1_2_8_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3688"},{"key":"e_1_2_8_167_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3441"},{"key":"e_1_2_8_168_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3862"},{"key":"e_1_2_8_169_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2017.62"},{"key":"e_1_2_8_170_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0313180"},{"key":"e_1_2_8_171_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010201107"},{"key":"e_1_2_8_172_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.7.4230"},{"key":"e_1_2_8_173_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201445016"},{"key":"e_1_2_8_174_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200007)30:7<1797::AID-IMMU1797>3.0.CO;2-B"},{"key":"e_1_2_8_175_1","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1126\/science.1105427","article-title":"Detection of a deep 3\u2010microm absorption feature in the spectrum of Amalthea (JV)","volume":"306","author":"Takato N","year":"2004","journal-title":"Science"},{"key":"e_1_2_8_176_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804286105"},{"key":"e_1_2_8_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.02.009"},{"key":"e_1_2_8_178_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.9.5467"},{"key":"e_1_2_8_179_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.12.7632"},{"key":"e_1_2_8_180_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni0308-233"},{"key":"e_1_2_8_181_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200402"},{"key":"e_1_2_8_182_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb08327.x"},{"key":"e_1_2_8_183_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"e_1_2_8_184_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"Team RDC","year":"2008"},{"key":"e_1_2_8_185_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btm254"},{"key":"e_1_2_8_186_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btm311"},{"key":"e_1_2_8_187_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3252"},{"key":"e_1_2_8_188_1","unstructured":"JWM.mogene10sttranscriptcluster.db: Affymetrix mogene10 annotation data (chip mogene10sttranscriptcluster). R package version 8.7.0;2017."},{"key":"e_1_2_8_189_1","unstructured":"MC.GO.db: A set of annotation maps describing the entire Gene Ontology. R package version 3.5.0;2017."},{"key":"e_1_2_8_190_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780090710"},{"key":"e_1_2_8_191_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr499"}],"container-title":["Immunological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimr.12649","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imr.12649","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T21:24:34Z","timestamp":1694467474000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imr.12649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,17]]},"references-count":190,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/imr.12649"],"URL":"https:\/\/doi.org\/10.1111\/imr.12649","archive":["Portico"],"relation":{},"ISSN":["0105-2896","1600-065X"],"issn-type":[{"value":"0105-2896","type":"print"},{"value":"1600-065X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,17]]},"assertion":[{"value":"2018-04-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}