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Infections with latent viruses, such as cytomegalovirus (<jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>), can lead to large T\u2010cell responses characterized by an oligoclonal <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content> repertoire. Here, we review the current status of experimental studies and theoretical models of <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content> repertoire evolution during <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> infection. We will particularly discuss the degree to which this process may be determined through structural <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content> avidity. As engineered <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>\u2010redirected T cells have moved into the spotlight for providing more effective immunotherapies, it is essential to understand how the key features of a given <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content> influence T\u2010cell expansion and maintenance in settings of infection or malignancy. Deeper insights into these mechanisms will improve our basic understanding of T\u2010cell immunology and help to identify optimal <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>s for immunotherapy.<\/jats:p>","DOI":"10.1111\/imr.12654","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T15:21:39Z","timestamp":1523978499000},"page":"113-128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["<scp>TCR<\/scp> repertoire evolution during maintenance of <scp>CMV<\/scp>\u2010specific T\u2010cell populations"],"prefix":"10.1111","volume":"283","author":[{"given":"Kilian","family":"Schober","sequence":"first","affiliation":[{"name":"Institute for Medical Microbiology, Immunology and Hygiene Technische Universit\u00e4t M\u00fcnchen (TUM)  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veit 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