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Although the most well recognized function of\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    4 T cells is provision of help for antibody production,\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    4 T cells are important in many aspects of protective immunity. Our studies have revealed that viral antigen specificity is a key determinant of\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    4 T cell function, as illustrated both by mouse models of infection and human vaccine responses, a factor whose importance is due at least in part to events in viral antigen handling. We discuss research that has provided insight into the diverse viral epitope specificity of\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    4 T cells elicited after infection, how this primary response is modified as\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    4 T cells home to the lung, establish memory, and after challenge with a secondary and distinct influenza virus strain. Our studies in human subjects point out the challenges facing vaccine efforts to facilitate responses to novel and avian strains of influenza, as well as strategies that enhance the ability of\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    4 T cells to promote protective antibody responses to both seasonal and potentially pandemic strains of influenza.\n                  <\/jats:p>","DOI":"10.1111\/imr.12662","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T14:28:30Z","timestamp":1530023310000},"page":"91-105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["<scp>CD<\/scp>\n                    4 T cells in protection from influenza virus: Viral antigen specificity and functional potential"],"prefix":"10.1111","volume":"284","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7176-7426","authenticated-orcid":false,"given":"Andrea J.","family":"Sant","sequence":"first","affiliation":[{"name":"David H. 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