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Despite many years of intense research, an aspect that still is not well understood is what (immune) mechanisms control the viral load during the prolonged asymptomatic stage of infection. Because <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8+ T cells have been implicated in this control by multiple lines of evidence, there has been a focus on understanding the potential mechanisms of action of this immune effector population. One type of experiment used to this end has been depleting these cells with monoclonal antibodies in the simian immunodeficiency virus\u2010macaque model and then studying the effect of that depletion on the viral dynamics. Here we review what these experiments have told us. We emphasize modeling studies to interpret the changes in viral load observed in these experiments, including discussion of alternative models, assumptions and interpretations, as well as potential future experiments.<\/jats:p>","DOI":"10.1111\/imr.12691","type":"journal-article","created":{"date-parts":[[2018,8,12]],"date-time":"2018-08-12T05:48:11Z","timestamp":1534052891000},"page":"26-37","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The dynamics of simian immunodeficiency virus after depletion of CD8+ cells"],"prefix":"10.1111","volume":"285","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8690-9896","authenticated-orcid":false,"given":"Erwing Fabian","family":"Cardozo","sequence":"first","affiliation":[{"name":"Vaccine and Infectious Disease Division Fred Hutchinson Cancer Research Center  Seattle, 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