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Recent research has shown that type 2 innate lymphoid cells (<jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>2s) contribute to steady\u2010state tissue integrity and exert tissue\u2010specific functions. However, upon exposure to inflammatory stimuli, they also initiate and amplify type 2 inflammation by inducing mucus production, eosinophilia, and Th2 differentiation. In this review, we discuss the regulation of <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>2 activation by transcription factors and metabolic pathways, as well as by extrinsic signals such as cytokines, lipid mediators, hormones, and neuropeptides. We also review recent discoveries about <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>2 plasticity and heterogeneity in different tissues, as revealed partly through single\u2010cell <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> sequencing of transcriptional responses to various stimuli. Understanding the tissue\u2010specific pathways that regulate <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>2 diversity and function is a critical step in the development of potential therapies for allergic diseases.<\/jats:p>","DOI":"10.1111\/imr.12702","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T01:29:11Z","timestamp":1538962151000},"page":"53-73","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Type 2 innate lymphoid cells in the induction and resolution of tissue inflammation"],"prefix":"10.1111","volume":"286","author":[{"given":"Antonia","family":"Wallrapp","sequence":"first","affiliation":[{"name":"Evergrande Center for Immunologic Diseases Harvard Medical School and Brigham &amp; Women's Hospital  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha J.","family":"Riesenfeld","sequence":"additional","affiliation":[{"name":"Klarman Cell Observatory Broad Institute of MIT and Harvard  Cambridge Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick R.","family":"Burkett","sequence":"additional","affiliation":[{"name":"Evergrande Center for Immunologic Diseases Harvard Medical School and Brigham &amp; Women's Hospital  Boston Massachusetts"},{"name":"Division of Pulmonary and Critical Care Medicine Department of Medicine Brigham &amp; Women's Hospital  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7177-2110","authenticated-orcid":false,"given":"Vijay K.","family":"Kuchroo","sequence":"additional","affiliation":[{"name":"Evergrande Center for Immunologic Diseases Harvard Medical School and Brigham &amp; Women's Hospital  Boston Massachusetts"},{"name":"Klarman Cell Observatory Broad Institute of MIT and Harvard  Cambridge 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