{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:28:12Z","timestamp":1791379692393,"version":"4.3.3"},"reference-count":95,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,7]],"date-time":"2018-10-07T00:00:00Z","timestamp":1538870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunological Reviews"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Group 2 innate lymphoid cells (\n                    <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>\n                    2s) are the most well defined group of\n                    <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>\n                    s.\n                    <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>\n                    2 development is controlled by the\n                    <jats:styled-content style=\"fixed-case\">GATA<\/jats:styled-content>\n                    \u20103 transcription factor and these cells produce archetypal type 2 cytokines, such as\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u20105 and\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201013. These cytokines mediate parasite expulsion and tissue repair, but also contribute to type 2 inflammatory diseases, including allergy, asthma and chronic rhinosinusitis with nasal polyps. In response to tightly regulated local environmental cues\n                    <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>\n                    s can generate characteristics of other subtypes, a process known as plasticity. Recent advances in the\n                    <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>\n                    2 field has led to the discovery that\n                    <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>\n                    2s can promptly shift to functional\n                    <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\n                    \u2010\u03b3\u2010producing\n                    <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>\n                    1s or\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201017\u2010producing\n                    <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>\n                    3s, depending on the cytokines and chemokines produced by antigen presenting cells or epithelial cells. Due to yet unknown triggers, this complex network of signals may become dysregulated. In this review, we will discuss general\n                    <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>\n                    characteristic,\n                    <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>\n                    2 development, plasticity, memory function, and implications in disease.\n                  <\/jats:p>","DOI":"10.1111\/imr.12708","type":"journal-article","created":{"date-parts":[[2018,10,7]],"date-time":"2018-10-07T21:29:11Z","timestamp":1538947751000},"page":"74-85","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["New insights into the function, development, and plasticity of type 2 innate lymphoid cells"],"prefix":"10.1111","volume":"286","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9679-8376","authenticated-orcid":false,"given":"Lisette","family":"Krabbendam","sequence":"first","affiliation":[{"name":"Department of Experimental Immunology Amsterdam\u2010UMC  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3133-6450","authenticated-orcid":false,"given":"Suzanne M.","family":"Bal","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunology Amsterdam\u2010UMC  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3269-8338","authenticated-orcid":false,"given":"Hergen","family":"Spits","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunology Amsterdam\u2010UMC  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4685-4592","authenticated-orcid":false,"given":"Korneliusz","family":"Golebski","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunology Amsterdam\u2010UMC  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000435"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13340"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1962"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.07.017"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3444"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.06.019"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.146"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3482"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.02.010"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1395"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2534"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12697"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14189"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07537"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1668"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.02.021"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091509"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1022"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202924"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3481"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501491"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3094"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.01.063"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.08.015"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08636"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08900"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1003988107"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.09.050"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00243-6"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.1.443"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2104"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3078"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2016.01.006"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.04406"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3248"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.030"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13047"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20172310"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.04.007"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.11.010"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00334"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2208"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.07.005"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20142224"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20150851"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.06.020"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2017.03.005"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.06.017"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201445339"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.03.039"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12643"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-008-0005-6"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1005641107"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.10.017"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2014.08.075"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3447"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3443"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0066-782X2012005000019"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13424"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2016.49.5.023"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02023-z"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.07.027"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2014.10.007"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152808"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087768"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.07.029"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.12.1086"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201609-1846OC"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201612-2427OC"},{"key":"e_1_2_10_71_1","first-page":"3","article-title":"European position paper on Rhinosinusitis and nasal polyps","volume":"2012","author":"Fokkens WJ","year":"2012","journal-title":"Rhinol Suppl"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12440"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12462"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2016.07.010"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0906312"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.06.038"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.05.037"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.11.037"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12540"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.06.024"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.03.032"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.02.038"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.12.1006"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.02.035"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145961"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12353"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20130351"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11394"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00391.x"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3005374"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0213084"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401307"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.01.007"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20130071"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2303"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01474.x"}],"container-title":["Immunological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimr.12708","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imr.12708","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T12:31:59Z","timestamp":1694435519000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imr.12708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,7]]},"references-count":95,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1111\/imr.12708"],"URL":"https:\/\/doi.org\/10.1111\/imr.12708","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.734201529.793582326","asserted-by":"object"}]},"ISSN":["0105-2896","1600-065X"],"issn-type":[{"value":"0105-2896","type":"print"},{"value":"1600-065X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,7]]},"assertion":[{"value":"2018-06-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}