{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:39:11Z","timestamp":1790847551559,"version":"4.1.0"},"reference-count":241,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T00:00:00Z","timestamp":1545091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001245","name":"Jeffrey Modell Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI067946"],"award-info":[{"award-number":["R01AI067946"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI120989"],"award-info":[{"award-number":["R01AI120989"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI137073"],"award-info":[{"award-number":["R01AI137073"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunological Reviews"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Human <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells are innate immune effectors that play a critical roles in the control of viral infection and malignancy. The importance of their homeostasis and function can be demonstrated by the study of patients with primary immunodeficiencies (<jats:styled-content style=\"fixed-case\">PIDs<\/jats:styled-content>), which are part of the family of diseases known as inborn defects of immunity. While <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells are affected in many <jats:styled-content style=\"fixed-case\">PID<\/jats:styled-content>s in ways that may contribute to a patient's clinical phenotype, a small number of <jats:styled-content style=\"fixed-case\">PID<\/jats:styled-content>s have an <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cell abnormality as their major immunological defect. These <jats:styled-content style=\"fixed-case\">PID<\/jats:styled-content>s can be collectively referred to as <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cell deficiency (<jats:styled-content style=\"fixed-case\">NKD<\/jats:styled-content>) disorders and include effects upon <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cell numbers, subsets, and\/or functions. The clinical impact of <jats:styled-content style=\"fixed-case\">NKD<\/jats:styled-content> can be severe including fatal viral infection, with particular susceptibility to herpesviral infections, such as cytomegalovirus, varicella zoster virus, and Epstein\u2010Barr virus. While <jats:styled-content style=\"fixed-case\">NKD<\/jats:styled-content> is rare, studies of these diseases are important for defining specific requirements for human <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cell development and homeostasis. New themes in <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cell biology are emerging through the study of both known and novel <jats:styled-content style=\"fixed-case\">NKD<\/jats:styled-content>, particularly those affecting cell cycle and <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> damage repair, as well as broader <jats:styled-content style=\"fixed-case\">PID<\/jats:styled-content>s having substantive impact upon <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells. In addition, the discovery of <jats:styled-content style=\"fixed-case\">NKD<\/jats:styled-content> that affects other innate lymphoid cell (<jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>) subsets opens new doors for better understanding the relationship between conventional <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells and other <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content> subsets. Here, we describe the biology underlying human <jats:styled-content style=\"fixed-case\">NKD<\/jats:styled-content>, particularly in the context of new insights into innate immune cell function, including a discussion of recently described <jats:styled-content style=\"fixed-case\">NKD<\/jats:styled-content> with accompanying effects on <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content> subsets. Given the impact of these disorders upon human immunity with a common focus upon <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells, the unifying message of a critical role for <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells in human host defense singularly emerges.<\/jats:p>","DOI":"10.1111\/imr.12725","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T01:12:24Z","timestamp":1545181944000},"page":"202-225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":182,"title":["Emerging insights into human health and <scp>NK<\/scp> cell biology from the study of <scp>NK<\/scp> cell deficiencies"],"prefix":"10.1111","volume":"287","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0226-7393","authenticated-orcid":false,"given":"Emily M.","family":"Mace","sequence":"first","affiliation":[{"name":"Department of Pediatrics Columbia University Irving Medical Center  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7117-7725","authenticated-orcid":false,"given":"Jordan S.","family":"Orange","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Columbia University Irving Medical Center  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.07.017"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.05.010"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3365"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701500"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-017-0464-9"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051568"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8202713"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8202712"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90368-9"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/376435a0"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80535-X"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.04.019"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13608"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar2641"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700453"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12318"},{"key":"e_1_2_11_18_1","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.4049\/jimmunol.118.4.1503","article-title":"Suppression of natural killer cell activity with radioactive strontium: effector cells are marrow dependent","volume":"118","author":"Haller O","year":"1977","journal-title":"J Immunol"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.139.5.1093"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198101000-00014"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.01.013"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2006.00451.x"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20052507"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00262"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.1.89"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-036228"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20082013"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.8.4947"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.3.2227"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-08-2568"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.01.020"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20171341"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030930"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-08-106294"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI46125"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830270612"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.12.5196.bloodjournal87125196"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.05.017"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2014.02.008"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1016257108"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201141760"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.10.008"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006702"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-2058"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-09-3682"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1110900108"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.04.005"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.02.013"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.02.008"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100762"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002268"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2011.0397"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283328d1f"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1086\/504719"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-04-419283"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.05.020"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.10.003"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00606-12"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.05.095"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2013.07.005"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12171"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2008.01.001"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-09-077438"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0181134"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-015-8664-y"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.09.009"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-11-427781"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-11-536888"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.02.021"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI90387"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1012356108"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2013.96"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-437012"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e09-11-0930"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201604136"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000326"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00080"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(02)00038-2"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.07.020"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-385377"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2478(00)00169-3"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.06.028"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.11.022"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1086\/503269"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.1.136"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(90)90155-W"},{"key":"e_1_2_11_87_1","first-page":"58","article-title":"Recalcitrant trichophytic granuloma associated with NK\u2010cell deficiency in a SLE patient treated with corticosteroid","volume":"11","author":"Akiba H","year":"2001","journal-title":"Eur J Dermatol"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198906293202605"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80572-6"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61014"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.04.021"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI90727"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI86276"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64837"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198207013070102"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-07-515528"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw160"},{"key":"e_1_2_11_98_1","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1182\/blood.V88.8.3022.bloodjournal8883022","article-title":"Identification of an unusual Fc gamma receptor IIIa (CD16) on natural killer cells in a patient with recurrent infections","volume":"88","author":"Vries E","year":"1996","journal-title":"Blood"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1068440"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3518"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1996.tb08295.x"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.170.2.481"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-58-1-173"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700950224"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/152.4.668"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-09-453969"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-07-517151"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.5MA0815-388R"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-08-734236"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.12.8835"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0034"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI60224"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes8020073"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2011.05.012"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1936"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20111908"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1100066"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.08.044"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-04-1088"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3197"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1104803"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.5.2573"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.26.021607.090400"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.04.018"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-013-1265-8"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1300600110"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt178"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00545"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00445"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70199-9"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-06-2104"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.08.040"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-499707"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-015-0145-5"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-11-122259"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20111229"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2013.01.004"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26217"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00855-9"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-02-074468"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.1999.2927"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.08.039"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-01-404350"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-1140"},{"key":"e_1_2_11_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.08.039"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-06-225359"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.06.049"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-014-0116-6"},{"key":"e_1_2_11_149_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23160"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1512234"},{"key":"e_1_2_11_151_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004430"},{"key":"e_1_2_11_152_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401463"},{"key":"e_1_2_11_153_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23435"},{"key":"e_1_2_11_154_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03822.x"},{"key":"e_1_2_11_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.278"},{"key":"e_1_2_11_156_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-0899"},{"key":"e_1_2_11_157_1","first-page":"151","article-title":"Humoral and cellular immune dysfunction in a patient with Bloom's syndrome and recurrent infections","volume":"28","author":"Etzioni A","year":"1989","journal-title":"J Clin Lab Immunol"},{"key":"e_1_2_11_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.06.009"},{"key":"e_1_2_11_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(98)00097-4"},{"key":"e_1_2_11_160_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-06-2114"},{"key":"e_1_2_11_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.12.1937"},{"key":"e_1_2_11_162_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1997.284-ce1174.x"},{"key":"e_1_2_11_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.11.042"},{"key":"e_1_2_11_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.01.026"},{"key":"e_1_2_11_165_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20112533"},{"key":"e_1_2_11_166_1","first-page":"673","article-title":"Identification of a phosphoinositide 3\u2010kinase (PI\u20103K) p110\u03b4 (PIK3CD) deficient individual","volume":"33","author":"Zhang KJ","year":"2013","journal-title":"J Clin Immunol"},{"key":"e_1_2_11_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.03.055"},{"key":"e_1_2_11_168_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1102140"},{"key":"e_1_2_11_169_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-12-469544"},{"key":"e_1_2_11_170_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.162376099"},{"key":"e_1_2_11_171_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1314975111"},{"key":"e_1_2_11_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.12.1568"},{"key":"e_1_2_11_173_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-344846"},{"key":"e_1_2_11_174_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110896"},{"key":"e_1_2_11_175_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1413462"},{"key":"e_1_2_11_176_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3575"},{"key":"e_1_2_11_177_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1240094"},{"key":"e_1_2_11_178_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1013285108"},{"key":"e_1_2_11_179_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102507"},{"key":"e_1_2_11_180_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-02-410795"},{"key":"e_1_2_11_181_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.6.2932"},{"key":"e_1_2_11_182_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-256099"},{"key":"e_1_2_11_183_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI37901"},{"key":"e_1_2_11_184_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0214858"},{"key":"e_1_2_11_185_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104765"},{"key":"e_1_2_11_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.11.038"},{"key":"e_1_2_11_187_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6360"},{"key":"e_1_2_11_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.01.011"},{"key":"e_1_2_11_189_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-04-571265"},{"key":"e_1_2_11_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2018.06.010"},{"key":"e_1_2_11_191_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01036"},{"key":"e_1_2_11_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2016.11.012"},{"key":"e_1_2_11_193_1","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.237"},{"key":"e_1_2_11_194_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.151.3706.81"},{"key":"e_1_2_11_195_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.6.1845"},{"key":"e_1_2_11_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.10.040"},{"key":"e_1_2_11_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2017.12.044"},{"key":"e_1_2_11_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.08.039"},{"key":"e_1_2_11_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.12.1337"},{"key":"e_1_2_11_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.02.031"},{"key":"e_1_2_11_201_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.13.2.133"},{"key":"e_1_2_11_202_1","first-page":"212","article-title":"Famili\u00e4rer, angeborener Morbus Werlhofii?","volume":"68","author":"Wiskott A","year":"1937","journal-title":"Monatsschr Kinderheilkd"},{"key":"e_1_2_11_203_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)82002-5"},{"key":"e_1_2_11_204_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI44862"},{"key":"e_1_2_11_205_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-07-2621"},{"key":"e_1_2_11_206_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.01.042"},{"key":"e_1_2_11_207_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1662"},{"key":"e_1_2_11_208_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-014-0074-8"},{"key":"e_1_2_11_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.03.049"},{"key":"e_1_2_11_210_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1243292"},{"key":"e_1_2_11_211_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.93"},{"key":"e_1_2_11_212_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2771"},{"key":"e_1_2_11_213_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20141759"},{"key":"e_1_2_11_214_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-08-801191"},{"key":"e_1_2_11_215_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-06-291633"},{"key":"e_1_2_11_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90167-O"},{"key":"e_1_2_11_217_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.9235"},{"key":"e_1_2_11_218_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13992"},{"key":"e_1_2_11_219_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10246"},{"key":"e_1_2_11_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.04.018"},{"key":"e_1_2_11_221_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.23.6963"},{"key":"e_1_2_11_222_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3625"},{"key":"e_1_2_11_223_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2004.01950.x"},{"key":"e_1_2_11_224_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803978105"},{"key":"e_1_2_11_225_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002732"},{"key":"e_1_2_11_226_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00798"},{"key":"e_1_2_11_227_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.08.026"},{"key":"e_1_2_11_228_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600789"},{"key":"e_1_2_11_229_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.11.031"},{"key":"e_1_2_11_230_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09135"},{"key":"e_1_2_11_231_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2013.04.003"},{"key":"e_1_2_11_232_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2007.02573.x"},{"key":"e_1_2_11_233_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9548"},{"key":"e_1_2_11_234_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13619"},{"key":"e_1_2_11_235_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-09-245464"},{"key":"e_1_2_11_236_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-08-752170"},{"key":"e_1_2_11_237_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3368"},{"key":"e_1_2_11_238_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.04.007"},{"key":"e_1_2_11_239_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.11.010"},{"key":"e_1_2_11_240_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa4282"},{"key":"e_1_2_11_241_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.09.013"},{"key":"e_1_2_11_242_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1706508114"}],"container-title":["Immunological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimr.12725","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imr.12725","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T18:10:07Z","timestamp":1694455807000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imr.12725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,18]]},"references-count":241,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1111\/imr.12725"],"URL":"https:\/\/doi.org\/10.1111\/imr.12725","archive":["Portico"],"relation":{},"ISSN":["0105-2896","1600-065X"],"issn-type":[{"value":"0105-2896","type":"print"},{"value":"1600-065X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,18]]},"assertion":[{"value":"2018-09-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}