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These decisions are paramount to overcome infection and establish long\u2010lasting protection. The impact of cell location for the determination of T\u2010cell fate decisions is an emerging field. This review will discuss our current understanding of the migration path that T cells follow, within draining lymph nodes, to steer differentiation down distinct paths of either effector or memory fates. In particular, the regulation of migration and cellular encounters mediated by the chemokine receptor <jats:styled-content style=\"fixed-case\">CXCR<\/jats:styled-content>3 and its ligands will be discussed. The combination of increased antigen density and unique cellular partners play a central role in facilitating the site\u2010specific differentiation of effector T cells, within the interfollicular regions of draining lymph nodes. Recent advances have applied this knowledge to optimize vaccine design to target antigen to lymph nodes. Increased understanding of the regulation of <jats:styled-content style=\"fixed-case\">CXCR<\/jats:styled-content>3 ligands and how T cells integrate multiple chemokine cues will help further progress in this field and allow additional applications to direct cell differentiation outside the lymph node, to enhance memory residency in peripheral tissues and effector anti\u2010tumor responses.<\/jats:p>","DOI":"10.1111\/imr.12742","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T10:25:26Z","timestamp":1555064726000},"page":"101-114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Regulators of T\u2010cell fate: Integration of cell migration, differentiation and function"],"prefix":"10.1111","volume":"289","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5251-7835","authenticated-orcid":false,"given":"Joanna 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