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In recent years, the advent of novel genomics technologies has revolutionized our understanding of the molecular pathogenesis of lymphoid malignancies as a multistep process that requires the progressive accumulation of multiple genetic and epigenetic alterations. A common theme that emerged from these studies is the ability of lymphoma cells to co\u2010opt the same biological programs and signal transduction networks that operate during the normal <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> reaction, and misuse them for their own survival advantage. This review summarizes recent progress in the understanding of the genetic and epigenetic mechanisms that drive the malignant transformation of <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> B cells. 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