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These alternate cell fate decisions, which ultimately control the T\u2010cell functional attributes, are dictated by programming signals provided by Ag\u2010bearing DCs and by other cells that are present in the microenvironment in which T\u2010cell priming occurs. We know that DCs can be subdivided into multiple populations and that the various DC subsets exhibit differential capacities to initiate development of the different CD4<jats:sup>+<\/jats:sup> T\u2010helper populations. What is less well understood is why different subanatomic regions of secondary lymphoid tissues are colonized by distinct populations of Ag\u2010presenting DCs and how the location of these DCs influences the type of T\u2010cell response that will be generated. Here we review how chemokine receptors and their ligands, which position allergen and nematode\u2010activated DCs within different microdomains of secondary lymphoid tissues, contribute to the establishment of IL\u20104 committed follicular helper T and type 2 helper cell responses.<\/jats:p>","DOI":"10.1111\/imr.12758","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T10:25:26Z","timestamp":1555064726000},"page":"84-100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Compartmentalization of dendritic cell and T\u2010cell interactions in the lymph node: Anatomy of T\u2010cell fate decisions"],"prefix":"10.1111","volume":"289","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3793-3854","authenticated-orcid":false,"given":"Beatriz","family":"Le\u00f3n","sequence":"first","affiliation":[{"name":"Department of Microbiology University of Alabama at Birmingham  Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3083-1246","authenticated-orcid":false,"given":"Frances E.","family":"Lund","sequence":"additional","affiliation":[{"name":"Department of Microbiology University of Alabama at Birmingham  Birmingham 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