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This personalized \u201cliving therapy\u201d is highly effective against a number of malignancies, but this efficacy is tempered by side effects relatively unique to immunotherapies, including CAR\u2010T. The overwhelming release of cytokines and chemokines by activated CAR\u2010T and other secondarily activated immune effector cells can lead to cytokine release syndrome (CRS), which can have clinical and pathophysiology similarities to systemic inflammatory response syndrome and macrophage activating syndrome\/hemophagocytic lymphohistiocytosis. Tocilizumab, an anti\u2010IL6 receptor antibody, was recently FDA approved for treatment of CRS after CAR\u2010T based on its ability to mitigate CRS in many patients. Unfortunately, some patients are refractory and additional therapies are needed. Patients treated with CAR\u2010T can also develop neurotoxicity and, as the biology is poorly understood, current therapeutic interventions are limited to supportive care. Nevertheless, a number of recent studies have shed new light on the pathophysiology of CAR\u2010T\u2010related neurotoxicity, which will hopefully lead to effective treatments. In this review we discuss some of the mechanistic contributions intrinsic to the CAR\u2010T construct, the tumor being treated, and the individual patient that impact the development and severity of CRS and neurotoxicity. As CAR\u2010T and cellular therapy have redefined the concept of personalized medicine, so too will personalization be necessary in managing the unique side effects of these therapies.<\/jats:p>","DOI":"10.1111\/imr.12768","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T06:12:12Z","timestamp":1564380732000},"page":"114-126","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Cellular therapy: Immune\u2010related complications"],"prefix":"10.1111","volume":"290","author":[{"given":"Joseph H.","family":"Oved","sequence":"first","affiliation":[{"name":"Divisions of Hematology and Oncology, Department of Pediatrics, Children\u2019s Hospital of Philadelphia University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David 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