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Antibodies also provide protection to reinfection. Long\u2010lasting B\u2010cell memory has been shown to occur in response to\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    spp. in experimental model infections, and in human malaria. However, there are reports that antibody responses to several malaria antigens in young children living with malaria are not similarly long\u2010lived, suggesting a dysfunction in the maintenance of circulating antibodies. Some studies attribute this to the expansion of atypical memory B cells (AMB), which express multiple inhibitory receptors and activation markers, and are hyporesponsive to B\u2010cell receptor (BCR) restimulation in vitro. AMB are also expanded in other chronic infections such as tuberculosis, hepatitis B and C, and HIV, as well as in autoimmunity and old age, highlighting the importance of understanding their role in immunity. Whether AMB are dysfunctional\u00a0remains controversial, as there are also studies in other infections showing that AMB can produce isotype\u2010switched antibodies and in mouse can contribute to protection against infection. In light of these controversies, we review the most recent literature on either side of the debate and challenge some of the currently held views regarding B\u2010cell responses to\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    infections.\n                  <\/jats:p>","DOI":"10.1111\/imr.12822","type":"journal-article","created":{"date-parts":[[2019,11,16]],"date-time":"2019-11-16T06:04:39Z","timestamp":1573884279000},"page":"57-69","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["B\u2010cell memory in malaria: Myths and realities"],"prefix":"10.1111","volume":"293","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2156-2585","authenticated-orcid":false,"given":"Dami\u00e1n","family":"P\u00e9rez\u2010Mazliah","sequence":"first","affiliation":[{"name":"The Francis Crick Institute London UK"},{"name":"York Biomedical Research Institute Hull York Medical School University of York 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