{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T07:51:52Z","timestamp":1773301912895,"version":"3.50.1"},"reference-count":82,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T00:00:00Z","timestamp":1592265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"The Ministry of Education, Culture, Sports, Science and Technology in Japan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005865","name":"The Mochida Memorial Foundation for Medical and Pharmaceutical Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005865","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Secom Science and Technology Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunological Reviews"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Influenza is one of the best examples of highly mutable viruses that are able to escape immune surveillance. Indeed, in response to influenza seasonal infection or vaccination, the majority of the induced antibodies are strain\u2010specific. Current vaccine against the seasonal strains with the strategy of surveillance\u2010prediction\u2010vaccine does not cover an unmet virus strain leading to pandemic. Recently, antibodies targeting conserved epitopes on the hemagglutinin (HA) protein have been identified, albeit rarely, and they often showed broad protection. These antibody discoveries have brought the feasibility to develop a universal vaccine. Most of these antibodies bind the HA stem domain and accumulate in the memory B cell compartment. Broadly reactive stem\u2010biased memory responses were induced by infection with antigenically divergent influenza strains and were able to eradicate these viruses, together indicating the importance of generating memory B cells expressing high\u2010quality anti\u2010stem antibodies. Here, we emphasize recent progress in our understanding of how such memory B cells can be generated and discuss how these advances may be relevant to the quest for a universal influenza vaccine.<\/jats:p>","DOI":"10.1111\/imr.12887","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T09:39:02Z","timestamp":1592300342000},"page":"132-141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Influenza vaccination strategies targeting the hemagglutinin stem region"],"prefix":"10.1111","volume":"296","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6457-0630","authenticated-orcid":false,"given":"Hidehiro","family":"Fukuyama","sequence":"first","affiliation":[{"name":"Laboratory for Lymphocyte Differentiation RIKEN Center for Integrative Medical Sciences (IMS) Yokohama Japan"},{"name":"Cellular Systems Laboratory Graduate School of Medical Life Science Yokohama City University Yokohama Japan"},{"name":"INSERM EST Strasbourg Cedex 2 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5369-3424","authenticated-orcid":false,"given":"Ryo","family":"Shinnakasu","sequence":"additional","affiliation":[{"name":"Laboratory of Lymphocyte Differentiation WPI Immunology Frontier Research Center Osaka University Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6352-304X","authenticated-orcid":false,"given":"Tomohiro","family":"Kurosaki","sequence":"additional","affiliation":[{"name":"Laboratory for Lymphocyte Differentiation RIKEN Center for Integrative Medical Sciences (IMS) Yokohama Japan"},{"name":"Laboratory of Lymphocyte Differentiation WPI Immunology Frontier Research Center Osaka University Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)33293-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.09.013"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)78541-2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI100853"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1962.03050400013003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-74529-4_12"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1201.051237"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400022610"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.24.1.157-160.1986"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.67.5.2552-2558.1993"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02975-12"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032712-095916"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3680"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004103"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2011.08.007"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11371"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aad0522"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09385"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-40175-8"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxz049"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12295-2"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006637"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01996-15"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.12.040194.001001"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/381751a0"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.09.001"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2016.12.004"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad3439"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3460"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.12.004"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1406974111"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aai8153"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3533"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.06.024"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.11.032"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3802"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01457"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3443"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI84428"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1205669"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1222908"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1171491"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1204839"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.09.010"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-77-7-1483"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1007465107"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00641-13"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac7263"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3927"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0912914107"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101633"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300770"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301285"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301283"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.06.003"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.09.001"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11821-6"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.04.011"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.08.031"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aag0851"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aab3964"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402071"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aal2094"},{"issue":"11","key":"e_1_2_7_65_1","first-page":"4351","article-title":"IL\u201018 and subcapsular lymph node macrophages are essential for enhanced B cell responses with TLR4 agonist","volume":"197","author":"Desbien AL","year":"2016","journal-title":"Adjuvants"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0068-4"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1323985111"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-02804-y"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/cti.2016.22"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601119"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep40312"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190301"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.10.069"},{"issue":"12","key":"e_1_2_7_74_1","first-page":"771","article-title":"Repurposing the Psoriasis Drug Oxarol to an ointment adjuvant for the influenza vaccine","volume":"31","author":"Sato R","year":"2019","journal-title":"Int Immunol"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.09.007"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4529"},{"key":"e_1_2_7_77_1","first-page":"1","article-title":"Is a universal influenza vaccine feasible?","volume":"7","author":"Phillipson JE","year":"2019","journal-title":"Ther Adv Vaccines Immunother"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/0264-410X(95)00088-I"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.04.089"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-019-0098-4"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1080\/10635150390235520"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz239"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.03.030"}],"container-title":["Immunological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimr.12887","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imr.12887","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imr.12887","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imr.12887","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T17:51:09Z","timestamp":1693936269000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imr.12887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,16]]},"references-count":82,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1111\/imr.12887"],"URL":"https:\/\/doi.org\/10.1111\/imr.12887","archive":["Portico"],"relation":{},"ISSN":["0105-2896","1600-065X"],"issn-type":[{"value":"0105-2896","type":"print"},{"value":"1600-065X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,16]]},"assertion":[{"value":"2020-03-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}