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In particular, an important role of IL\u201017A\u2013producing \u03b3\u03b4 T cells in these inflammatory skin diseases has been shown in various disease models in mice. Interestingly, various epidermal proteins, which appear to be linked to inflammatory conditions in the skin by yet undescribed mechanisms, are expressed by specific subsets of thymic epithelial cells and mutations in these proteins seem to affect \u03b3\u03b4 T cell development. The focus of this review is how mutations in epidermal proteins affect \u03b3\u03b4 T cell development and how \u03b3\u03b4 T cells, and in particular of IL\u201017A\u2013producing \u03b3\u03b4 T cells, contribute to inflammatory skin diseases such as allergic contact dermatitis, psoriasis, and atopic dermatitis.<\/jats:p>","DOI":"10.1111\/imr.12913","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T18:36:15Z","timestamp":1599071775000},"page":"61-73","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["\u03b3\u03b4 T cells and inflammatory skin diseases"],"prefix":"10.1111","volume":"298","author":[{"given":"Mia Hamilton","family":"Jee","sequence":"first","affiliation":[{"name":"The LEO Foundation Skin Immunology Research Center Department of Immunology and Microbiology Faculty of Health and Medical Sciences University of Copenhagen Copenhagen 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