{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T08:45:35Z","timestamp":1791449135382,"version":"4.3.3"},"reference-count":147,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T00:00:00Z","timestamp":1605398400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["CoG_676401"],"award-info":[{"award-number":["CoG_676401"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunological Reviews"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The contributions of \u03b3\u03b4 T cells to immune (patho)physiology in many pre\u2010clinical mouse models have been associated with their rapid and abundant provision of two critical cytokines, interferon\u2010\u03b3 (IFN\u2010\u03b3) and interleukin\u201017A (IL\u201017). These are typically produced by distinct effector \u03b3\u03b4 T cell subsets that can be segregated on the basis of surface expression levels of receptors such as CD27, CD44 or CD45RB, among others. Unlike conventional T cells that egress the thymus as na\u00efve lymphocytes awaiting further differentiation upon activation, a large fraction of murine \u03b3\u03b4 T cells commits to either IFN\u2010\u03b3 or IL\u201017 expression during thymic development. However, extrathymic signals can both regulate pre\u2010programmed \u03b3\u03b4 T cells; and induce peripheral differentiation of na\u00efve \u03b3\u03b4 T cells into effectors. Here we review the key cellular events of \u201cdevelopmental pre\u2010programming\u201d in the mouse thymus; and the molecular basis for effector function maintenance vs plasticity in the periphery. We highlight some of our contributions towards elucidating the role of T cell receptor, co\u2010receptors (like CD27 and CD28) and cytokine signals (such as IL\u20101\u03b2 and IL\u201023) in these processes, and the various levels of gene regulation involved, from the chromatin landscape to microRNA\u2010based post\u2010transcriptional control of \u03b3\u03b4 T cell functional plasticity.<\/jats:p>","DOI":"10.1111\/imr.12918","type":"journal-article","created":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T02:16:51Z","timestamp":1605493011000},"page":"47-60","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["From thymus to periphery: Molecular basis of effector \u03b3\u03b4\u2010T cell differentiation"],"prefix":"10.1111","volume":"298","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8226-5584","authenticated-orcid":false,"given":"Gina J.","family":"Fiala","sequence":"first","affiliation":[{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes Faculdade de Medicina Universidade de Lisboa Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3348-0448","authenticated-orcid":false,"given":"Anita Q.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes Faculdade de Medicina Universidade de Lisboa Lisbon Portugal"},{"name":"H&amp;TRC Health &amp; Technology Research Center ESTeSL\u2014Escola Superior de Tecnologia da Sa\u00fade Instituto Polit\u00e9cnico de Lisboa Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4141-9302","authenticated-orcid":false,"given":"Bruno","family":"Silva\u2010Santos","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes Faculdade de Medicina Universidade de Lisboa Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri797"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0303738101"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/322836a0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/335443a0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.149.9.2872"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90139-0"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/343754a0"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aay5199"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.06.003"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20181206"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.5.2413"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800934"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3904"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.175.1.49"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.06.015"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.01.011"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.7.4466"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00796"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3726"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.05.071"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13839"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00118"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.10.023"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20181439"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7477"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.9.5940"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.04.022"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1717"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2005.04.004"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050085"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.6.3739"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1103978"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500375"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.06.011"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14760"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04076-0"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.3.1710"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939922"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4986"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.05.064"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01963-w"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5451.314"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3424"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1814440116"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051886"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070782"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1371"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903895106"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903218"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.10.007"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.04.018"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.09.010"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI95837"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002766"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13032"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.05.010"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20072425"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2820"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.6.689"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.12.2233"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.7.973"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.6.1045"},{"key":"e_1_2_8_64_1","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.4049\/jimmunol.156.8.2723","article-title":"Role of IL\u20107 in the shaping of the pulmonary gamma delta T cell repertoire","volume":"156","author":"Hayes SM","year":"1996","journal-title":"J Immunol"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.8.4087"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1135344"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.01.010"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2585"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.04.003"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.03.014"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046590"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/13.1.105"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701521"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302145"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.05.004"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2247"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2782"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.04.015"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-030409-101212"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05587.x"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.154"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.05.009"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.01.056"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.12.009"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2702"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1115980109"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501921"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-09-378653"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1993"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.4.1566"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.09.016"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201142155"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2017.01.007"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-02-334995"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.02.019"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2587"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2019104159"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.09.044"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.05.003"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.082701.108"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3838"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081219"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050678"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050572"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081062"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061692"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020171"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1221984110"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.03.008"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145010"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aao1392"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101823"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20112218"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0605298103"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.056317"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2010.09.005"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.08.012"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501822"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2286"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature17631"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2012.11.004"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002283"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200268"},{"key":"e_1_2_8_124_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/978-1-4614-6217-0_11","article-title":"Differentiation and activation of gammadelta T Lymphocytes: focus on CD27 and CD28 costimulatory receptors","volume":"785","author":"Ribot JC","year":"2013","journal-title":"Adv Exp Med Biol"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201242842"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2013.18"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.10.017"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500448"},{"key":"e_1_2_8_129_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1204327109"},{"key":"e_1_2_8_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.08.001"},{"key":"e_1_2_8_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2773"},{"key":"e_1_2_8_132_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.10087"},{"key":"e_1_2_8_133_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201744200"},{"key":"e_1_2_8_134_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700287"},{"key":"e_1_2_8_135_1","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.12164"},{"key":"e_1_2_8_136_1","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.12196"},{"key":"e_1_2_8_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0304-y"},{"key":"e_1_2_8_138_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2006.00469.x"},{"key":"e_1_2_8_139_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501220"},{"key":"e_1_2_8_140_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9040800"},{"key":"e_1_2_8_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0094-2"},{"key":"e_1_2_8_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2028-z"},{"key":"e_1_2_8_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10928"},{"key":"e_1_2_8_144_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1818812116"},{"key":"e_1_2_8_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-019-0153-5"},{"key":"e_1_2_8_146_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0038-z"},{"key":"e_1_2_8_147_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1019574108"},{"key":"e_1_2_8_148_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1802320115"}],"container-title":["Immunological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imr.12918","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imr.12918","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imr.12918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T12:54:01Z","timestamp":1693832041000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imr.12918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":147,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1111\/imr.12918"],"URL":"https:\/\/doi.org\/10.1111\/imr.12918","archive":["Portico"],"relation":{},"ISSN":["0105-2896","1600-065X"],"issn-type":[{"value":"0105-2896","type":"print"},{"value":"1600-065X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"2020-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}