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There is currently an unmet need for new management and treatment strategies. Establishment of an anti\u2010CMV immune response is critical in order to control CMV infection. The two main human T cells involved in HCMV\u2010specific response are \u03b1\u03b2 and non\u2010V\u03b39V\u03b42 T cells that belong to \u03b3\u03b4 T cell compartment. CMV\u2010induced non\u2010V\u03b39V\u03b42 T cells harbor a specific clonal expansion and a phenotypic signature, and display effector functions against CMV. So far, only two main molecular mechanisms underlying CMV sensing have been identified. Non\u2010V\u03b39V\u03b42 T cells can be activated either by stress\u2010induced surface expression of the \u03b3\u03b4T cell receptor (TCR) ligand annexin A2, or by a multimolecular stress signature composed of the \u03b3\u03b4TCR ligand endothelial protein C receptor and co\u2010stimulatory signals such as the ICAM\u20101\u2010LFA\u20101 axis. All this basic knowledge can be harnessed to improve the clinical management of CMV infection in at\u2010risk patients. In particular, non\u2010V\u03b39V\u03b42 T cell monitoring could help better stratify the risk of infection and move forward a personalized medicine. Moreover, recent advances in cell therapy protocols open the way for a non\u2010V\u03b39V\u03b42 T cell therapy in immunocompromised patients.<\/jats:p>","DOI":"10.1111\/imr.12922","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T13:24:35Z","timestamp":1603373075000},"page":"264-288","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Understanding human \u03b3\u03b4 T cell biology toward a better management of cytomegalovirus infection"],"prefix":"10.1111","volume":"298","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1604-3825","authenticated-orcid":false,"given":"Hannah","family":"Kaminski","sequence":"first","affiliation":[{"name":"ImmunoConcEpT UMR 5164 CNRS Bordeaux University  Bordeaux France"},{"name":"Department of Nephrology, Transplantation, Dialysis and Apheresis Bordeaux University Hospital  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9200-2454","authenticated-orcid":false,"given":"Gabriel","family":"Mars\u00e8res","sequence":"additional","affiliation":[{"name":"ImmunoConcEpT UMR 5164 CNRS Bordeaux University  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana\u00efs","family":"Cosentino","sequence":"additional","affiliation":[{"name":"ImmunoConcEpT UMR 5164 CNRS Bordeaux University  Bordeaux France"},{"name":"Department of Nephrology, Transplantation, Dialysis and Apheresis Bordeaux University Hospital  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Guerville","sequence":"additional","affiliation":[{"name":"ImmunoConcEpT UMR 5164 CNRS Bordeaux University  Bordeaux France"},{"name":"CHU Bordeaux P\u00f4le de g\u00e9rontologie, Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Pitard","sequence":"additional","affiliation":[{"name":"ImmunoConcEpT UMR 5164 CNRS Bordeaux University  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Jacques","family":"Fourni\u00e9","sequence":"additional","affiliation":[{"name":"Centre de Recherches en Canc\u00e9rologie de Toulouse (CRCT) UMR1037 INSERM Universit\u00e9 Toulouse III: Paul\u2010Sabatier, ERL5294 CNRS Universit\u00e9 de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Merville","sequence":"additional","affiliation":[{"name":"ImmunoConcEpT UMR 5164 CNRS Bordeaux University  Bordeaux France"},{"name":"Department of Nephrology, Transplantation, Dialysis and Apheresis Bordeaux University Hospital  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7521-9531","authenticated-orcid":false,"given":"Julie","family":"D\u00e9chanet\u2010Merville","sequence":"additional","affiliation":[{"name":"ImmunoConcEpT UMR 5164 CNRS Bordeaux University  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9213-6196","authenticated-orcid":false,"given":"Lionel","family":"Couzi","sequence":"additional","affiliation":[{"name":"ImmunoConcEpT UMR 5164 CNRS Bordeaux University  Bordeaux France"},{"name":"Department of Nephrology, Transplantation, Dialysis and Apheresis Bordeaux University Hospital  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2034"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw668"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03074.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318238dab3"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002191"},{"key":"e_1_2_9_7_1","first-page":"423","article-title":"One and half million hematopoietic stem cell transplants (HSCT). 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