{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:44:58Z","timestamp":1790613898315,"version":"4.1.0"},"reference-count":162,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T00:00:00Z","timestamp":1609891200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009614","name":"Petroleum Technology Development Fund","doi-asserted-by":"publisher","award":["SHS\/1327\/18"],"award-info":[{"award-number":["SHS\/1327\/18"]}],"id":[{"id":"10.13039\/501100009614","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunological Reviews"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>B cells are critical mediators of humoral immune responses in the airways through antibody production, antigen presentation, and cytokine secretion. In addition, a subset of B cells, known as regulatory B cells (Bregs), exhibit immunosuppressive functions via diverse regulatory mechanisms. Bregs modulate immune responses via the secretion of IL\u201010, IL\u201035, and tumor growth factor\u2010\u03b2 (TGF\u2010\u03b2), and by direct cell contact. The balance between effector and regulatory B cell functions is critical in the maintenance of immune homeostasis. The importance of Bregs in airway immune responses is emphasized by the different respiratory disorders associated with abnormalities in Breg numbers and function. In this review, we summarize the role of immunosuppressive Bregs in airway inflammatory diseases and highlight the importance of this subset in the maintenance of respiratory health. We propose that improved understanding of signals in the lung microenvironment that drive Breg differentiation can provide novel therapeutic avenues for improved management of respiratory diseases.<\/jats:p>","DOI":"10.1111\/imr.12941","type":"journal-article","created":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T06:25:34Z","timestamp":1610259934000},"page":"61-73","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Regulatory B cells in respiratory health and diseases"],"prefix":"10.1111","volume":"299","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2516-9438","authenticated-orcid":false,"given":"Madhvi","family":"Menon","sequence":"first","affiliation":[{"name":"Lydia Becker Institute of Immunology and Inflammation Division of Infection Immunity &amp; Respiratory Medicine School of Biological Sciences Faculty of Biology, Medicine and Health University of Manchester Manchester Academic Health Science Centre Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Hussell","sequence":"additional","affiliation":[{"name":"Lydia Becker Institute of Immunology and Inflammation Division of Infection Immunity &amp; Respiratory Medicine School of Biological Sciences Faculty of Biology, Medicine and Health University of Manchester Manchester Academic Health Science Centre Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halima","family":"Ali Shuwa","sequence":"additional","affiliation":[{"name":"Lydia Becker Institute of Immunology and Inflammation Division of Infection Immunity &amp; Respiratory Medicine School of Biological Sciences Faculty of Biology, Medicine and Health University of Manchester Manchester Academic Health Science Centre Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.02.023"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-020711-074934"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxv038"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI85113"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00304.2016"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-014-0304-0"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2012.01.007"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12238"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39437"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3680"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.02.012"},{"issue":"5","key":"e_1_2_10_13_1","first-page":"2110","article-title":"IFN\u2010\u03b2 treatment requires B cells for efficacy in neuroautoimmunity","volume":"194","author":"Schubert RD","year":"2015","journal-title":"J Immunol Baltim Md 1950"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11501"},{"issue":"7","key":"e_1_2_10_15_1","first-page":"3321","article-title":"Novel function of B cell\u2010activating factor in the induction of IL\u201010\u2010producing regulatory B cells","volume":"184","author":"Yang M","year":"2010","journal-title":"J Immunol Baltim Md 1950"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3554"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033628"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201344341"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.10.018"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107892"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00267-X"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01909"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.10.016"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12979"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02768"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01368"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2018.09.012"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.01.018"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000718"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep11554"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.12.7868"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902385"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.11.009"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2015.10.023"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102880"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1109173109"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803052"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI46274"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402632"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6997"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-294249"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.01.014"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-3450"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400336"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-02-482406"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-1213-9"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxz068"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-017-0391-3"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3005407"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.02.008"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-02911-y"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.12.5897"},{"issue":"2","key":"e_1_2_10_53_1","first-page":"1081","article-title":"Lipopolysaccharide\u2010activated B cells down\u2010regulate Th1 immunity and prevent autoimmune diabetes in nonobese diabetic mice","volume":"167","author":"Tian J","year":"2001","journal-title":"J Immunol Baltim Md 1950"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2015.02.004"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1999.00644.x"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2007.12.004"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00477"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.3.364"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3MR0218-062R"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01639"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2017.13"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636136"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01924"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02469"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12554"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0260-6"},{"issue":"1","key":"e_1_2_10_67_1","doi-asserted-by":"crossref","first-page":"85.8","DOI":"10.4049\/jimmunol.204.Supp.85.8","article-title":"Lung resident memory B cells are a common and functionally significant component of lung adaptive immunity","volume":"204","author":"Barker KA","year":"2020","journal-title":"J Immunol"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2009.02319.x"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.10.39"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.19.8796"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1439"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00283.x"},{"issue":"9","key":"e_1_2_10_73_1","first-page":"6309","article-title":"An indispensable role for the chemokine receptor CCR10 in IgA antibody secreting cell accumulation","volume":"181","author":"Morteau O","year":"2008","journal-title":"J Immunol Baltim Md 1950"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1203"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(02)00206-7"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20010685"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1115369109"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.4.1350"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161161"},{"issue":"1","key":"e_1_2_10_80_1","doi-asserted-by":"crossref","first-page":"71.3","DOI":"10.4049\/jimmunol.198.Supp.71.3","article-title":"Tissue resident memory B cells established in lungs in allergic asthma","volume":"198","author":"Turner DL","year":"2017","journal-title":"J Immunol"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201646518"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201010-1605OC"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032158"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201507-1311OC"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201403-0529OC"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200504-594OC"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S40673"},{"issue":"5","key":"e_1_2_10_88_1","first-page":"2089","article-title":"Plasma B lymphocyte stimulator and B cell differentiation in idiopathic pulmonary fibrosis patients","volume":"191","author":"Xue J","year":"2013","journal-title":"J Immunol Baltim Md 1950"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916934.2019.1700232"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/681678"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2018.01.002"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2018.1"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28756"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22847"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.11311"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2015.10.005"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.01.1223"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13589"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110036"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201206-1024OC"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev331"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/347141"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.02.007"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtauto.2019.100011"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/149185"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-019-02461-2"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2005-0158OE"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-15-1408"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2018.1513440"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxw007"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2017.35"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5588"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-3077"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-4316"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064159"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.6605"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2020.03.032"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02049-2020"},{"key":"e_1_2_10_119_1","article-title":"Dominant extrafollicular B cell responses in severe COVID\u201019 disease correlate with robust viral\u2010specific antibody production but poor clinical outcomes","author":"Woodruff M","year":"2020","journal-title":"medRxiv"},{"key":"e_1_2_10_120_1","doi-asserted-by":"crossref","DOI":"10.2139\/ssrn.3720301","volume-title":"Long\u2010Lasting Alterations in T and B Cell Function in Convalescent COVID\u201019 Patients","author":"Shuwa HA","year":"2020"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0346-x"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.01.010"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12114"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/874021"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12574"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939721"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030883"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2019.04.012"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05674-8"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00210.2018"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2009.09.005"},{"issue":"63","key":"e_1_2_10_132_1","first-page":"PA4362","article-title":"B cells are crucial in the regulation of airway hyperreactivity in an experimental model of asthma","volume":"54","author":"Habener A","year":"2019","journal-title":"Eur Respir J"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.03034"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.03.024"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2039"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200504-045SR"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-018-0730-2"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-019-1216-6"},{"issue":"3","key":"e_1_2_10_139_1","first-page":"224","article-title":"Pulmonary manifestations of systemic autoimmune diseases","volume":"6","author":"Cojocaru M","year":"2011","journal-title":"M\u00e6dica"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4571"},{"issue":"2","key":"e_1_2_10_141_1","first-page":"A63","article-title":"II\u201007 Pathogenesis of pulmonary lupus and vasculitis: trafficking of innate B1 B cells to the lungs as a novel mechanism","volume":"5","author":"Singh RR","year":"2018","journal-title":"Lupus Sci Amp Med"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21758"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-013-2359-3"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep356"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1159\/000156965"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.4103\/atm.ATM_30_17"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.14306"},{"issue":"10","key":"e_1_2_10_148_1","first-page":"5982","article-title":"Novel human transitional B cell populations revealed by B cell depletion therapy","volume":"182","author":"Palanichamy A","year":"2009","journal-title":"J Immunol Baltim Md 1950"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22810"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.12.025"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2007.02729.x"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-2113.197116"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep34424"},{"issue":"2","key":"e_1_2_10_154_1","first-page":"47","article-title":"HIF\u2010mediated innate immune responses: cell signaling and therapeutic implications","volume":"24","author":"Harris AJ","year":"2014","journal-title":"Hypoxia"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02683-x"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-013-0391-7"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202001529R"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/372384"},{"issue":"3","key":"e_1_2_10_159_1","first-page":"1036","article-title":"Regulatory B10 cells differentiate into antibody\u2010secreting cells after transient IL\u201010 production in vivo","volume":"188","author":"Maseda D","year":"2012","journal-title":"J Immunol Baltim Md 1950"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneumo.2011.04.004"},{"issue":"1","key":"e_1_2_10_161_1","first-page":"53","article-title":"Immunotherapy in lung cancer","volume":"3","author":"Massarelli E","year":"2014","journal-title":"Transl Lung Cancer Res"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcz162"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2017.03.118"}],"container-title":["Immunological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imr.12941","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imr.12941","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imr.12941","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T16:17:00Z","timestamp":1693585020000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imr.12941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":162,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/imr.12941"],"URL":"https:\/\/doi.org\/10.1111\/imr.12941","archive":["Portico"],"relation":{},"ISSN":["0105-2896","1600-065X"],"issn-type":[{"value":"0105-2896","type":"print"},{"value":"1600-065X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2020-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}