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In particular, lymphoid stromal cells (LSCs) form a phenotypically heterogeneous compartment including various cell subsets variably supporting B\u2010cell survival, activation, proliferation, and differentiation. In turn, activated B cells trigger in\u2010depth remodeling of LSC networks within lymph nodes (LN) and BM. Follicular lymphoma (FL) is one of the best paradigms of a B\u2010cell neoplasia depending on a specific tumor microenvironment (TME), including cancer\u2010associated fibroblasts (CAFs) emerging from the reprogramming of LN LSCs or poorly characterized local BM precursors. FL\u2010CAFs support directly malignant B\u2010cell growth and orchestrate FL permissive cell niche by contributing, through a bidirectional crosstalk, to the recruitment and polarization of immune TME subsets. Recent studies have highlighted a previously unexpected level of heterogeneity of both FL B cells and FL TME, underlined by FL\u2010CAF plasticity. 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