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Adventitial fibroblasts (AFs), a subtype of mesenchymal stromal cell, are the dominant constituents in adventitial spaces, regulating vascular integrity while organizing the accumulation and activation of a variety of interacting immune cells. In contrast, pericytes are stromal mural cells that support microvascular capillaries and surround organ\u2010specific parenchymal cells. Here, we outline the unique immune and non\u2010immune composition of perivascular tissue immune niches, with an emphasis on the heterogeneity and immunoregulatory functions of AFs and pericytes across diverse organs. We will discuss how perivascular stromal cells contribute to the regulation of innate and adaptive immune responses and integrate immunological signals to impact tissue health and disease.<\/jats:p>","DOI":"10.1111\/imr.12984","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T04:27:21Z","timestamp":1622608041000},"page":"10-31","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Perivascular stromal cells: Directors of tissue immune niches"],"prefix":"10.1111","volume":"302","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7133-5332","authenticated-orcid":false,"given":"Julia","family":"Sbierski\u2010Kind","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine University of California San Francisco San Francisco CA 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