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There is keen interest in manipulating thymic function for therapeutic purposes in circumstances of autoimmunity, immunodeficiency, and for purposes of immunotherapy. Within the thymus, thymic epithelial cells play essential roles in directing T cell development.\u00a0Several transcription factors are known to be essential for thymic epithelial cell development and function, and a few transcription factors have been studied in considerable detail. However, the role of many other transcription factors is less well understood. Further, it is likely that roles exist for other transcription factors not yet known to be important in thymic epithelial cells. Recent progress in understanding of thymic epithelial cell heterogeneity has provided some new insight into transcriptional requirements in subtypes of thymic epithelial cells. However, it is unknown whether progenitors of thymic epithelial cells exist in the adult thymus, and consequently, developmental relationships linking putative precursors with differentiated cell types are poorly understood. While we do not presently possess a clear understanding of stage\u2010specific requirements for transcription factors in thymic epithelial cells, new single\u2010cell transcriptomic and epigenomic technologies should enable rapid progress in this field. Here, we review our current knowledge of transcription factors involved in the development, maintenance, and function of thymic epithelial cells, and the mechanisms by which they act.<\/jats:p>","DOI":"10.1111\/imr.13034","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T04:46:24Z","timestamp":1636433184000},"page":"43-58","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Transcriptional and epigenetic regulation in thymic epithelial cells*"],"prefix":"10.1111","volume":"305","author":[{"given":"Gustavo Ulises","family":"Martinez\u2010Ru\u00edz","sequence":"first","affiliation":[{"name":"T Cell Biology and Development Unit Laboratory of Genome Integrity Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda MD USA"},{"name":"Research Division Faculty of Medicine National Autonomous University of Mexico Mexico City Mexico"},{"name":"Children's 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