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Direct microscopic imaging of the involved immune cells, especially neutrophil granulocytes, monocytes, and macrophages, has been performed since more than 150\u00a0years, and we still obtain novel insights on a frequent basis. Initially, intravital microscopy was limited to small\u2010sized animal species, which were often invertebrates. In this review, we will discuss recent results on the biology of neutrophils and macrophages that have been obtained using confocal and two\u2010photon microscopy of individual cells or subcellular structures as well as light\u2010sheet microscopy of entire organs. This includes the role of these cells in infection defense and sterile inflammation in mammalian disease models relevant for human patients. We discuss their protective but also disease\u2010enhancing activities during tumor growth and ischemia\u2010reperfusion damage of the heart and brain. 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