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Although non\u2010protein antigens are not recognized by T cells, antibody production to non\u2010protein antigens involve T cell\u2013independent mechanisms such as signaling through TLR7 and TLR9 in antibody production to nucleic acids. Although self\u2010reactive B cells are tolerized by various mechanisms including deletion, anergy, and receptor editing, T cell tolerance is also crucial in self\u2010tolerance of B cells to protein self\u2010antigen because self\u2010reactive T cells induce autoantibody production to these self\u2010antigens. However, presence of T cell\u2013independent mechanism suggests that T cell tolerance is not able to maintain B cell tolerance to non\u2010protein self\u2010antigens. Lines of evidence suggest that B cell response to non\u2010protein self\u2010antigens such as nucleic acids and gangliosides, sialic acid\u2010containing glycolipids, are suppressed by inhibitory B cell co\u2010receptors CD72 and Siglec\u2010G, respectively. These inhibitory co\u2010receptors recognize non\u2010protein self\u2010antigens and suppress BCR signaling induced by these antigens, thereby inhibiting B cell response to these self\u2010antigens. Inhibitory B cell co\u2010receptors appear to be involved in B cell self\u2010tolerance to non\u2010protein self\u2010antigens that can activate B cells by T cell\u2013independent mechanisms.<\/jats:p>","DOI":"10.1111\/imr.13059","type":"journal-article","created":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T04:34:01Z","timestamp":1641443641000},"page":"53-65","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Role of inhibitory B cell co\u2010receptors in B cell self\u2010tolerance to non\u2010protein antigens*"],"prefix":"10.1111","volume":"307","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0760-1258","authenticated-orcid":false,"given":"Takeshi","family":"Tsubata","sequence":"first","affiliation":[{"name":"Department of Immunology Medical Research Institute Tokyo Medical and Dental University  Tokyo 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