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While microglia are largely responsible for surveying the parenchyma, CNS barrier sites are inhabited by a plethora of different innate and adaptive immune cells that participate in everything from the defense against microbes to the maintenance of neural function. Static and dynamic imaging studies have revolutionized the field of neuroimmunology by providing detailed maps of CNS immune cells as well as information about how these cells move, organize, and interact during steady\u2010state and inflammatory conditions. These studies have also redefined our understanding of neural\u2010immune interactions at a cellular level and reshaped our conceptual view of immune privilege in this specialized compartment. 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