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The initiators of the inflammatory signaling mechanism can be both maternal and fetal. The placental (fetal)\u2010maternal immune and endocrine mediated homeostatic imbalances and inflammation are well reported. However, the fetal inflammatory response (FIR) theories initiated by the fetal membranes (amniochorion) at the choriodecidual interface are not well established. Although immune cell migration, activation, and production of proparturition cytokines to the fetal membranes are reported, cellular level events that can generate a unique set of inflammation are not well discussed. This review discusses derangements to fetal membrane cells (physiologically and pathologically at term and preterm, respectively) in response to both endogenous and exogenous factors to generate inflammatory signals. In addition, the mechanisms of inflammatory signal propagation (fetal signaling of parturition) and how these signals cause immune imbalances at the choriodecidual interface are discussed. In addition to maternal inflammation, this review projects FIR as an additional mediator of inflammatory overload required to promote parturition.<\/jats:p>","DOI":"10.1111\/imr.13075","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T12:44:54Z","timestamp":1647261894000},"page":"149-167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Fetal inflammatory response at the fetomaternal interface: A\u00a0requirement for labor at term and preterm*"],"prefix":"10.1111","volume":"308","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9213-6105","authenticated-orcid":false,"given":"Ramkumar","family":"Menon","sequence":"first","affiliation":[{"name":"Division of Basic Science and Translational Research Department of Obstetrics &amp; Gynecology The University of Texas Medical Branch Galveston Texas 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