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Children generally present with less severe disease from this virus compared with adults, yet neonates and children with COVID\u201019 can require hospitalization, and older children can develop severe complications, such as the multisystem inflammatory syndrome, resulting in &gt;1500 deaths in children from COVID\u201019 since the onset of the pandemic. The introduction of effective SARS\u2010CoV\u20102 vaccines in school\u2010age children and adult populations combined with the emergence of new, more highly transmissible SARS\u2010CoV\u20102 variants has resulted in a proportional increase of infections in young children. Here, we discuss (1) the current knowledge on pediatric SARS\u2010CoV\u20102 infection and pathogenesis in comparison with adults, (2) the data on vaccine immunogenicity and efficacy in children, and (3) the benefits of early life SARS\u2010CoV\u20102 vaccination.<\/jats:p>","DOI":"10.1111\/imr.13108","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T06:08:55Z","timestamp":1657260535000},"page":"90-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Routine <scp>SARS\u2010CoV<\/scp>\u20102 vaccination for all children*"],"prefix":"10.1111","volume":"309","author":[{"given":"Kristina","family":"De Paris","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Center for AIDS Research, and Children\u2019s Research Institute, School of Medicine University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1438-4554","authenticated-orcid":false,"given":"Sallie R.","family":"Permar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Weill Cornell Medicine\/ New York Presbyterian  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.3199"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n1197"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.8707"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.08.037"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-01227-z"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2012358117"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2020-321334"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/Spectrum.00783-21"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2021.05.012"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abf8609"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.148694"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04345-x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14345"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr2011679"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0337-y"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.04.042"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1202870109"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2021-0292OC"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20200652"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-171629"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101287"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2022.37.e35"},{"key":"e_1_2_12_24_1","unstructured":"Organization WH.2022.covid19.who.int. 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