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Torrey TCD award"],"award-info":[{"award-number":["EndMS David L. Torrey TCD award"]}],"id":[{"id":"10.13039\/501100000261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["5K01NS097519\u201003"],"award-info":[{"award-number":["5K01NS097519\u201003"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunological Reviews"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Inflammation is a biological process that dynamically alters the surrounding microenvironment, including participating immune cells. As a well\u2010protected organ surrounded by specialized barriers and with immune privilege properties, the central nervous system (CNS) tightly regulates immune responses. Yet in neuroinflammatory conditions, pathogenic immunity can disrupt CNS structure and function. T cells in particular play a key role in promoting and restricting neuroinflammatory responses, while the inflamed CNS microenvironment can influence and reshape T cell function and identity. Still, the contraction of aberrant T cell responses within the CNS is not well understood. Using autoimmunity as a model, here we address the contribution of CD4 T helper (Th) cell subsets in promoting neuropathology and disease. To address the mechanisms antagonizing neuroinflammation, we focus on the control of the immune response by regulatory T cells (Tregs) and describe the counteracting processes that preserve their identity under inflammatory challenges. Finally, given the influence of the local microenvironment on immune regulation, we address how CNS\u2010intrinsic signals reshape T cell function to mitigate abnormal immune T cell responses.<\/jats:p>","DOI":"10.1111\/imr.13122","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T03:44:25Z","timestamp":1659325465000},"page":"151-176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Neuroinflammation: Extinguishing a blaze of T cells"],"prefix":"10.1111","volume":"311","author":[{"given":"Nail","family":"Benallegue","sequence":"first","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Center for Research in Transplantation and Translational Immunology Nantes Universit\u00e9, CHU Nantes, INSERM, UMR 1064  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hania","family":"Kebir","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8216-5129","authenticated-orcid":false,"given":"Jorge I.","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine University of Pennsylvania  Philadelphia Pennsylvania 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