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In their absence or when they are functionally defective, as occurs in certain congenital disorders, affected individuals develop severe forms of periodontitis in early age. These observations imply that the presence of immune\u2010competent neutrophils is essential to homeostasis. However, the presence of supernumerary or hyper\u2010responsive neutrophils, either because of systemic priming or innate immune training, leads to imbalanced host\u2013microbe interactions in the periodontium that culminate in dysbiosis and inflammatory tissue breakdown. These disease\u2010provoking imbalanced interactions are further exacerbated by periodontal pathogens capable of subverting neutrophil responses to their microbial community's benefit and the host's detriment. This review attempts a synthesis of these findings for an integrated view of the neutrophils' ambivalent role in periodontal disease and, moreover, discusses how some of these concepts underpin the development of novel therapeutic approaches to treat periodontal disease.<\/jats:p>","DOI":"10.1111\/imr.13152","type":"journal-article","created":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T09:30:35Z","timestamp":1666431035000},"page":"93-110","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Neutrophils in the periodontium: Interactions with pathogens and roles in tissue homeostasis and inflammation"],"prefix":"10.1111","volume":"314","author":[{"given":"Silvia M.","family":"Uriarte","sequence":"first","affiliation":[{"name":"Department of Oral Immunology and Infectious Diseases, School of Dentistry University of Louisville  Louisville Kentucky 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