{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:01:12Z","timestamp":1791518472818,"version":"4.3.4"},"reference-count":428,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["EQU202003010155"],"award-info":[{"award-number":["EQU202003010155"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018737","name":"Laboratoire d'Excellence Inflamex","doi-asserted-by":"publisher","award":["ANR\u201011\u2010IDEX\u20100005\u201002"],"award-info":[{"award-number":["ANR\u201011\u2010IDEX\u20100005\u201002"]}],"id":[{"id":"10.13039\/100018737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunological Reviews"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The term \u201cvasculitis\u201d refers to a group of rare immune\u2010mediated diseases characterized by the dysregulated immune system attacking blood vessels located in any organ of the body, including the skin, lungs, and kidneys. Vasculitides are classified according to the size of the vessel that is affected. Although this observation is not specific to small\u2010, medium\u2010, or large\u2010vessel vasculitides, patients show a high circulating neutrophil\u2010to\u2010lymphocyte ratio, suggesting the direct or indirect involvement of neutrophils in these diseases. As first responders to infection or inflammation, neutrophils release cytotoxic mediators, including reactive oxygen species, proteases, and neutrophil extracellular traps. If not controlled, this dangerous arsenal can injure the vascular system, which acts as the main transport route for neutrophils, thereby amplifying the initial inflammatory stimulus and the recruitment of immune cells. This review highlights the ability of neutrophils to \u201cset the tone\u201d for immune cells and other cells in the vessel wall. Considering both their long\u2010established and newly described roles, we extend their functions far beyond their direct host\u2010damaging potential. We also review the roles of neutrophils in various types of primary vasculitis, including immune complex vasculitis, anti\u2010neutrophil cytoplasmic antibody\u2010associated vasculitis, polyarteritis nodosa, Kawasaki disease, giant cell arteritis, Takayasu arteritis, and Beh\u00e7et's disease.<\/jats:p>","DOI":"10.1111\/imr.13170","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T12:15:30Z","timestamp":1669032930000},"page":"326-356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["The neutrophil: A key resourceful agent in immune\u2010mediated vasculitis"],"prefix":"10.1111","volume":"314","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9587-8822","authenticated-orcid":false,"given":"Karen","family":"Aymonnier","sequence":"first","affiliation":[{"name":"INSERM U1016, Institut Cochin, Universit\u00e9 Paris Cit\u00e9, CNRS 8104  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7049-2926","authenticated-orcid":false,"given":"Jennifer","family":"Amsler","sequence":"additional","affiliation":[{"name":"INSERM U1016, Institut Cochin, Universit\u00e9 Paris Cit\u00e9, CNRS 8104  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5929-868X","authenticated-orcid":false,"given":"Peter","family":"Lamprecht","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9255-9092","authenticated-orcid":false,"given":"Alan","family":"Salama","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Royal Free Hospital University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5296-9601","authenticated-orcid":false,"given":"V\u00e9ronique","family":"Witko\u2010Sarsat","sequence":"additional","affiliation":[{"name":"INSERM U1016, Institut Cochin, Universit\u00e9 Paris Cit\u00e9, CNRS 8104  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,21]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1785"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3RI0917-361R"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2021.101506"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz084"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.619705"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2018.08.010"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32835ad3ca"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1361.075"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021.102829"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2020.102992"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.09.023"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37715"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370206"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-021-00738-4"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000528"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2021.04.002"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3399"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.10.008"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2011.06.009"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv044"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2011.06.008"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-0412-0"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2016.12.012"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2008.03.010"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.789172"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0326-7"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.310694"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2016.03.006"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4776"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI133661"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aal2379"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021.103016"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780067"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.371"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1159\/000525357"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830271008"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.771170"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2012.07.015"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2206"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12350"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12337"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01958"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00811"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.12.4387"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2014.01.024"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0910500"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01380217"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.5.1544"},{"key":"e_1_2_13_50_1","first-page":"813","article-title":"Human tissue distribution of novel basement membrane collagen","volume":"134","author":"Kleppel MM","year":"1989","journal-title":"Am J Pathol"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy327"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102618"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.03.014"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.122.1.99"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-014-0435-7"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI3256"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.11.1853"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2021111460"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-03915-2"},{"key":"e_1_2_13_60_1","first-page":"1404","article-title":"Interleukin 1 receptor antagonist gene polymorphism is associated with severe renal involvement and renal sequelae in Henoch\u2010Sch\u00f6nlein purpura","volume":"29","author":"Amoli MM","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22147538"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000019"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-021-01182-6"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200109000-00001"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2018-0841"},{"key":"e_1_2_13_66_1","first-page":"371","article-title":"Fifteen\u2010year experience of children with Henoch\u2010Sch\u00f6nlein purpura in southern Taiwan, 1991\u20102005","volume":"40","author":"Nong B\u2010R","year":"2007","journal-title":"J Microbiol Immunol Infect"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-022-01082-6"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.10.009"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez041"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03076.x"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2018.05.016"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300261"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400028"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900883"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbacli.2016.02.002"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.912929"},{"key":"e_1_2_13_77_1","article-title":"Neutrophil extracellular traps are present in immune\u2010complex\u2010mediated cutaneous small vessel Vasculitis and correlate with the production of reactive oxygen species and the severity of vessel damage","volume":"100","author":"Bergqvist C","year":"2020","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.668974"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-007-0475-5"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02824"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-12-401133"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400478"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfaa206"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-018-0145-y"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.06.016"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2015.03.012"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)91147-X"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126474"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2019.06.004"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.627776"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.12.004"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2015.10.006"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00680"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2007.11.005"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0204-y"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203255"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2018.10.002"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1108735"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207601"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI160089"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40034"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2021081142"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330807"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330806"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-221795"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-221794"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-221796"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20077"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1002\/prot.21853"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1210695"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-015-0279-z"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1959"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2016.03.004"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2007.00550.x"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12441"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060815-014442"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0712349"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00044.x"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-020712-163936"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hco.0000231402.87232.aa"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2021.03.032"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.434613"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.04.014"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.01.013"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1006\/clim.1999.4696"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2121-15-21"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.6.1709"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90752-6"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.8.2449"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2010.07659.x"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.110.002733"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1841"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010080892"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M702876200"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.25006"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.295055"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803624"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V1061224"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000040751.83734.D1"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.7.2487.419k07_2487_2496"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3MR0217-069R"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0806514"},{"key":"e_1_2_13_143_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-055327"},{"key":"e_1_2_13_144_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2010.04154.x"},{"key":"e_1_2_13_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2005.03.034"},{"key":"e_1_2_13_146_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M806754200"},{"key":"e_1_2_13_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.101598"},{"key":"e_1_2_13_148_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.698639"},{"key":"e_1_2_13_149_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012020119"},{"key":"e_1_2_13_150_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200006)43:6<1337::AID-ANR16>3.0.CO;2-M"},{"key":"e_1_2_13_151_1","first-page":"1617","article-title":"Apoptosis of endothelial cells induced by the neutrophil serine proteases proteinase 3 and elastase","volume":"149","author":"Yang JJ","year":"1996","journal-title":"Am J Pathol"},{"key":"e_1_2_13_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12269-6"},{"key":"e_1_2_13_153_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.50.6.539"},{"key":"e_1_2_13_154_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2012.04615.x"},{"key":"e_1_2_13_155_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-213523"},{"key":"e_1_2_13_156_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.171256"},{"key":"e_1_2_13_157_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-0994-1"},{"key":"e_1_2_13_158_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4575"},{"key":"e_1_2_13_159_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013111177"},{"key":"e_1_2_13_160_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1708247114"},{"key":"e_1_2_13_161_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215918"},{"key":"e_1_2_13_162_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.826515"},{"key":"e_1_2_13_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62951-3"},{"key":"e_1_2_13_164_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.0590051729.x"},{"key":"e_1_2_13_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61400-7"},{"key":"e_1_2_13_166_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-01-0267"},{"key":"e_1_2_13_167_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.064626"},{"key":"e_1_2_13_168_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.5A0116-037R"},{"key":"e_1_2_13_169_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028626"},{"key":"e_1_2_13_170_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI65292"},{"key":"e_1_2_13_171_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2009.67"},{"key":"e_1_2_13_172_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12171"},{"key":"e_1_2_13_173_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2002.01864.x"},{"key":"e_1_2_13_174_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30362"},{"key":"e_1_2_13_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2017.01.033"},{"key":"e_1_2_13_176_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.149"},{"key":"e_1_2_13_177_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2019060618"},{"key":"e_1_2_13_178_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002371"},{"key":"e_1_2_13_179_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.638571"},{"key":"e_1_2_13_180_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40034"},{"key":"e_1_2_13_181_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016050548"},{"key":"e_1_2_13_182_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013101092"},{"key":"e_1_2_13_183_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.13.6454"},{"key":"e_1_2_13_184_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032439"},{"key":"e_1_2_13_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.02.017"},{"key":"e_1_2_13_186_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.649693"},{"key":"e_1_2_13_187_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-04-713206"},{"key":"e_1_2_13_188_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12448"},{"key":"e_1_2_13_189_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02603"},{"key":"e_1_2_13_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.04.037"},{"key":"e_1_2_13_191_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39153"},{"key":"e_1_2_13_192_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2012.04633.x"},{"key":"e_1_2_13_193_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0240-6"},{"key":"e_1_2_13_194_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-042617-053010"},{"key":"e_1_2_13_195_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916930701357208"},{"key":"e_1_2_13_196_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01708"},{"key":"e_1_2_13_197_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-080457"},{"key":"e_1_2_13_198_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200600"},{"key":"e_1_2_13_199_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00818"},{"key":"e_1_2_13_200_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI78182"},{"key":"e_1_2_13_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2017.05.004"},{"key":"e_1_2_13_202_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601522"},{"key":"e_1_2_13_203_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2022.2088940"},{"key":"e_1_2_13_204_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2018.10.003"},{"key":"e_1_2_13_205_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-018-0525-8"},{"key":"e_1_2_13_206_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000001106"},{"key":"e_1_2_13_207_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1307362"},{"key":"e_1_2_13_208_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330805"},{"key":"e_1_2_13_209_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-020-04535-2"},{"key":"e_1_2_13_210_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-021-04867-7"},{"key":"e_1_2_13_211_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-022-00918-8"},{"key":"e_1_2_13_212_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2018892752"},{"key":"e_1_2_13_213_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2638"},{"issue":"117","key":"e_1_2_13_214_1","first-page":"79","article-title":"Serum lysosomal\u2010associated membrane protein\u20102 levels are increased in small and medium\u2010vessel vasculitis, especially in polyarteritis nodosa","volume":"37","author":"Li N","year":"2019","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_13_215_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-003-0851-x"},{"key":"e_1_2_13_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2014.01.029"},{"key":"e_1_2_13_217_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74594-9"},{"key":"e_1_2_13_218_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1996.tb33304.x"},{"key":"e_1_2_13_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.05.002"},{"key":"e_1_2_13_220_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.517391"},{"key":"e_1_2_13_221_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003319717751758"},{"key":"e_1_2_13_222_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.097097"},{"key":"e_1_2_13_223_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1167-6"},{"key":"e_1_2_13_224_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.11.029"},{"key":"e_1_2_13_225_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-021-00718-8"},{"key":"e_1_2_13_226_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.05.034"},{"key":"e_1_2_13_227_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13213"},{"key":"e_1_2_13_228_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-0426-0"},{"key":"e_1_2_13_229_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31103-X"},{"key":"e_1_2_13_230_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31094-1"},{"key":"e_1_2_13_231_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.048360"},{"key":"e_1_2_13_232_1","unstructured":"ToubianaJ PoiraultC CorsiaA et al.Outbreak of Kawasaki disease in children during COVID\u201019 pandemic: a prospective observational study in Paris France.medRxiv.2020.10.1101\/2020.05.10.20097394"},{"key":"e_1_2_13_233_1","unstructured":"Paediatric multisystem inflammatory syndrome temporally associated with COVID\u201019 (PIMS) \u2010 guidance for clinicians.RCPCH.https:\/\/www.rcpch.ac.uk\/resources\/paediatric\u2010multisystem\u2010inflammatory\u2010syndrome\u2010temporally\u2010associated\u2010covid\u201019\u2010pims\u2010guidance"},{"key":"e_1_2_13_234_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210446"},{"key":"e_1_2_13_235_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-12-0568"},{"key":"e_1_2_13_236_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0217274"},{"key":"e_1_2_13_237_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000484"},{"key":"e_1_2_13_238_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2018-3675"},{"key":"e_1_2_13_239_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32003-8"},{"key":"e_1_2_13_240_1","article-title":"Corticosteroids for the treatment of Kawasaki disease in children","volume":"1","author":"Wardle AJ","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_13_241_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198812223192515"},{"key":"e_1_2_13_242_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-014-0102-6"},{"key":"e_1_2_13_243_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13314"},{"key":"e_1_2_13_244_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00163"},{"key":"e_1_2_13_245_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24838"},{"key":"e_1_2_13_246_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.03.046"},{"key":"e_1_2_13_247_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.072769"},{"key":"e_1_2_13_248_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2019.11.158"},{"key":"e_1_2_13_249_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24851"},{"key":"e_1_2_13_250_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.06.028"},{"key":"e_1_2_13_251_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021005949"},{"key":"e_1_2_13_252_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201466"},{"key":"e_1_2_13_253_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.02.004"},{"key":"e_1_2_13_254_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3CE1118-433R"},{"key":"e_1_2_13_255_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.4HI0918-346R"},{"key":"e_1_2_13_256_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24959"},{"key":"e_1_2_13_257_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.11.6261"},{"key":"e_1_2_13_258_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI147076"},{"key":"e_1_2_13_259_1","doi-asserted-by":"publisher","DOI":"10.1006\/clim.2002.5209"},{"key":"e_1_2_13_260_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2001.01675.x"},{"key":"e_1_2_13_261_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11112035"},{"key":"e_1_2_13_262_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2017.02.011"},{"key":"e_1_2_13_263_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200x.2005.02049.x"},{"key":"e_1_2_13_264_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02829.x"},{"key":"e_1_2_13_265_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2020.108385"},{"key":"e_1_2_13_266_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951100000408"},{"key":"e_1_2_13_267_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000113464.93042.A4"},{"key":"e_1_2_13_268_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-008-0872-1"},{"key":"e_1_2_13_269_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.00391"},{"key":"e_1_2_13_270_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-14-1323"},{"key":"e_1_2_13_271_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2012.719946"},{"key":"e_1_2_13_272_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-0492-x"},{"key":"e_1_2_13_273_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.640315"},{"key":"e_1_2_13_274_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6663291"},{"key":"e_1_2_13_275_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210706"},{"key":"e_1_2_13_276_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-019-0710-3"},{"key":"e_1_2_13_277_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20200928"},{"key":"e_1_2_13_278_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.13240"},{"key":"e_1_2_13_279_1","first-page":"410","article-title":"Values of neutrophil\u2010lymphocyte ratio and platelet\u2010lymphocyte ratio in predicting sensitivity to intravenous immunoglobulin in Kawasaki disease","volume":"19","author":"Yuan Y\u2010D","year":"2017","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"key":"e_1_2_13_280_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-020-02285-5"},{"key":"e_1_2_13_281_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200101000-00017"},{"key":"e_1_2_13_282_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-019-0315-8"},{"key":"e_1_2_13_283_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36520-y"},{"key":"e_1_2_13_284_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2007.03326.x"},{"key":"e_1_2_13_285_1","first-page":"265","article-title":"Expression of CD11b as an adhesion molecule on neutrophils in children with Kawasaki disease","volume":"13","author":"Heidari B","year":"2014","journal-title":"Iran J Allergy Asthma Immunol"},{"key":"e_1_2_13_286_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-016-0942-1"},{"key":"e_1_2_13_287_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1999.00970.x"},{"key":"e_1_2_13_288_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.05.076"},{"key":"e_1_2_13_289_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23042"},{"key":"e_1_2_13_290_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.930547"},{"key":"e_1_2_13_291_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-018-0557-1"},{"key":"e_1_2_13_292_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.03048"},{"key":"e_1_2_13_293_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.014822"},{"key":"e_1_2_13_294_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.00295"},{"key":"e_1_2_13_295_1","doi-asserted-by":"publisher","DOI":"10.1136\/jim-2020-001281"},{"key":"e_1_2_13_296_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.623716"},{"key":"e_1_2_13_297_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00327-5"},{"key":"e_1_2_13_298_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-212649"},{"key":"e_1_2_13_299_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215672"},{"key":"e_1_2_13_300_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-220873"},{"key":"e_1_2_13_301_1","unstructured":"University Hospital Caen.Randomized controlled double\u2010blind study of anakinra against placebo in addition to steroids in giant cell arteritis.2020.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02902731"},{"key":"e_1_2_13_302_1","unstructured":"AbbVie.A multicenter randomized double\u2010blind placebo\u2010controlled study to evaluate the safety and efficacy of Upadacitinib in subjects with Giant cell arteritis: select\u2010GCA.2022.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03725202"},{"key":"e_1_2_13_303_1","unstructured":"Novartis Pharmaceuticals.A randomized parallel group double blind placebo controlled multicenter phase III trial to investigate the efficacy and safety of secukinumab 300 mg administered subcutaneously versus placebo in combination with glucocorticoid taper regimen in patients with giant cell arteritis (GCA).2022.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04930094"},{"key":"e_1_2_13_304_1","unstructured":"Centre Hospitalier Universitaire Dijon.Ustekinumab for the treatment of relapse of refractory giant cell arteritis.2022.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03711448"},{"key":"e_1_2_13_305_1","unstructured":"Janssen Research & Development LLC.A phase 2 multicenter randomized placebo\u2010controlled double\u2010blind proof\u2010of\u2010concept study to evaluate guselkumab for the treatment of participants with new\u2010onset or relapsing giant cell arteritis.2022.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04633447"},{"key":"e_1_2_13_306_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg116"},{"key":"e_1_2_13_307_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.11.013"},{"key":"e_1_2_13_308_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32833ee946"},{"key":"e_1_2_13_309_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.587089"},{"key":"e_1_2_13_310_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200008)43:8<1749::AID-ANR11>3.0.CO;2-K"},{"key":"e_1_2_13_311_1","first-page":"1215","article-title":"Intercellular adhesion molecule 1 gene polymorphisms in polymyalgia rheumatica\/giant cell arteritis: association with disease risk and severity","volume":"27","author":"Salvarani C","year":"2000","journal-title":"J Rheumatol"},{"key":"e_1_2_13_312_1","first-page":"1737","article-title":"A functional variant of vascular endothelial growth factor is associated with severe ischemic complications in giant cell arteritis","volume":"32","author":"Rueda B","year":"2005","journal-title":"J Rheumatol"},{"key":"e_1_2_13_313_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.081286"},{"key":"e_1_2_13_314_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1616848114"},{"key":"e_1_2_13_315_1","doi-asserted-by":"publisher","DOI":"10.1002\/cti2.1332"},{"key":"e_1_2_13_316_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000244"},{"key":"e_1_2_13_317_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1660"},{"key":"e_1_2_13_318_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab505"},{"key":"e_1_2_13_319_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01981"},{"key":"e_1_2_13_320_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.13713"},{"key":"e_1_2_13_321_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-63824-9"},{"key":"e_1_2_13_322_1","doi-asserted-by":"publisher","DOI":"10.1002\/cti2.1307"},{"key":"e_1_2_13_323_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.33411"},{"key":"e_1_2_13_324_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.301374"},{"key":"e_1_2_13_325_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02491"},{"key":"e_1_2_13_326_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916930902832629"},{"key":"e_1_2_13_327_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.139163"},{"key":"e_1_2_13_328_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25220"},{"key":"e_1_2_13_329_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202160"},{"key":"e_1_2_13_330_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01744544"},{"key":"e_1_2_13_331_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22931"},{"key":"e_1_2_13_332_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1808850115"},{"key":"e_1_2_13_333_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2020.11.014"},{"key":"e_1_2_13_334_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02644.x"},{"key":"e_1_2_13_335_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-019-04818-5"},{"key":"e_1_2_13_336_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41774"},{"key":"e_1_2_13_337_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-014451"},{"key":"e_1_2_13_338_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.912495"},{"key":"e_1_2_13_339_1","article-title":"Increased circulating Th17 cells, serum IL\u201017A, and IL\u201023 in Takayasu arteritis","volume":"2016","author":"Misra DP","year":"2016","journal-title":"Autoimmune Dis"},{"key":"e_1_2_13_340_1","first-page":"S27","article-title":"Interleukin\u20108 in Takayasu's arteritis: plasma levels and relationship with disease activity","volume":"22","author":"Tripathy NK","year":"2004","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_13_341_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kei266"},{"key":"e_1_2_13_342_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874312901711010023"},{"key":"e_1_2_13_343_1","doi-asserted-by":"publisher","DOI":"10.1177\/000331970005100705"},{"key":"e_1_2_13_344_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.10.2396"},{"key":"e_1_2_13_345_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/36.8.923"},{"key":"e_1_2_13_346_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2069.107235"},{"key":"e_1_2_13_347_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00393-020-00809-z"},{"key":"e_1_2_13_348_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2012.07.007"},{"key":"e_1_2_13_349_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab788"},{"key":"e_1_2_13_350_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21103685"},{"key":"e_1_2_13_351_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-019-0746-x"},{"key":"e_1_2_13_352_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01166-6"},{"key":"e_1_2_13_353_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI156876"},{"key":"e_1_2_13_354_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24642"},{"key":"e_1_2_13_355_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2011.05.002"},{"key":"e_1_2_13_356_1","first-page":"808","article-title":"2018 update of the EULAR recommendations for the management of Beh\u00e7et's syndrome","volume":"77","author":"Hatemi G","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_13_357_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2000.00859.x"},{"key":"e_1_2_13_358_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-022-02637-1"},{"key":"e_1_2_13_359_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00417153"},{"key":"e_1_2_13_360_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.38.3.219"},{"key":"e_1_2_13_361_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.30.3.250"},{"key":"e_1_2_13_362_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab052"},{"key":"e_1_2_13_363_1","first-page":"1332","article-title":"Changes of neutrophil migration without modification of in vitro metabolism and adhesion in Beh\u00e7et's disease","volume":"24","author":"Carletto A","year":"1997","journal-title":"J Rheumatol"},{"key":"e_1_2_13_364_1","first-page":"S85","article-title":"Beh\u00e7et's disease heterogeneity: cytokine production and oxidative burst of phagocytes are altered in patients with severe manifestations","volume":"33","author":"Perazzio SF","year":"2015","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_13_365_1","first-page":"247","article-title":"Auto\u2010oxidative damage in Beh\u00e7et's disease\u2010\u2010endothelial cell damage following the elevated oxygen radicals generated by stimulated neutrophils","volume":"49","author":"Niwa Y","year":"1982","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_13_366_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.590622"},{"key":"e_1_2_13_367_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214335"},{"key":"e_1_2_13_368_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.55.2.128"},{"key":"e_1_2_13_369_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2011.23.3.313"},{"key":"e_1_2_13_370_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13664"},{"key":"e_1_2_13_371_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.07.069"},{"key":"e_1_2_13_372_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12950-022-00302-1"},{"key":"e_1_2_13_373_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.017738"},{"key":"e_1_2_13_374_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01085"},{"key":"e_1_2_13_375_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.304114"},{"key":"e_1_2_13_376_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00236"},{"key":"e_1_2_13_377_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.16391"},{"key":"e_1_2_13_378_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1005743107"},{"key":"e_1_2_13_379_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-10-463646"},{"key":"e_1_2_13_380_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2013.06.004"},{"key":"e_1_2_13_381_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4294"},{"key":"e_1_2_13_382_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.105"},{"key":"e_1_2_13_383_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)80031-6"},{"key":"e_1_2_13_384_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa251"},{"key":"e_1_2_13_385_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker177"},{"key":"e_1_2_13_386_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-007-0470-y"},{"key":"e_1_2_13_387_1","doi-asserted-by":"publisher","DOI":"10.1080\/02713680490904331"},{"key":"e_1_2_13_388_1","first-page":"2151","article-title":"High mobility group box 1 serum levels are increased in Beh\u00e7et's disease, but not associated with disease activity or disease manifestations","volume":"54","author":"Souza AWS","year":"2015","journal-title":"Rheumatology (Oxford)"},{"key":"e_1_2_13_389_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1256478"},{"key":"e_1_2_13_390_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0223444"},{"key":"e_1_2_13_391_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1565"},{"key":"e_1_2_13_392_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-013-0375-7"},{"key":"e_1_2_13_393_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2018.10.008"},{"key":"e_1_2_13_394_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex338"},{"key":"e_1_2_13_395_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2019.10.005"},{"key":"e_1_2_13_396_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2023386"},{"key":"e_1_2_13_397_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.12.014"},{"key":"e_1_2_13_398_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101763"},{"key":"e_1_2_13_399_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V12137"},{"key":"e_1_2_13_400_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.06.044"},{"key":"e_1_2_13_401_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13705"},{"key":"e_1_2_13_402_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000048715.12315.FD"},{"key":"e_1_2_13_403_1","article-title":"209. Inhibition of PEPTIDYLARGININE deiminase 4 limits neutrophil extracellular trap formation and inflammation IN experimental anti MPO\u2010ANCA glomerulonephritis","volume":"58","author":"O'Sullivan KM","year":"2019","journal-title":"Rheumatology"},{"key":"e_1_2_13_404_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2018.05.011"},{"key":"e_1_2_13_405_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez061.011"},{"key":"e_1_2_13_406_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2021081112"},{"key":"e_1_2_13_407_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12121222"},{"key":"e_1_2_13_408_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-018-0074-7"},{"key":"e_1_2_13_409_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1595-3"},{"key":"e_1_2_13_410_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.150999"},{"key":"e_1_2_13_411_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909905"},{"key":"e_1_2_13_412_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1404231"},{"key":"e_1_2_13_413_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez640"},{"key":"e_1_2_13_414_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13005"},{"key":"e_1_2_13_415_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-06-789578"},{"key":"e_1_2_13_416_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez597"},{"key":"e_1_2_13_417_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209133"},{"key":"e_1_2_13_418_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11279-7"},{"key":"e_1_2_13_419_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40178"},{"key":"e_1_2_13_420_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2005.05.003"},{"key":"e_1_2_13_421_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.13591215"},{"key":"e_1_2_13_422_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2011.02621.x"},{"key":"e_1_2_13_423_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem107"},{"key":"e_1_2_13_424_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41776"},{"key":"e_1_2_13_425_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330811"},{"key":"e_1_2_13_426_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-017-1479-6"},{"key":"e_1_2_13_427_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330810"},{"key":"e_1_2_13_428_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.02.006"},{"key":"e_1_2_13_429_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00301-1"}],"container-title":["Immunological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imr.13170","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imr.13170","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imr.13170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T14:20:34Z","timestamp":1695997234000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imr.13170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,21]]},"references-count":428,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1111\/imr.13170"],"URL":"https:\/\/doi.org\/10.1111\/imr.13170","archive":["Portico"],"relation":{},"ISSN":["0105-2896","1600-065X"],"issn-type":[{"value":"0105-2896","type":"print"},{"value":"1600-065X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,21]]},"assertion":[{"value":"2022-11-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}