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COVID\u201019 is a respiratory disease characterized by pulmonary dysfunction leading to acute respiratory distress syndrome (ARDs), as well as disseminated coagulation, and multi\u2010organ dysfunction. Neutrophils and neutrophil extracellular traps (NETs) have been implicated in the pathogenesis of COVID\u201019. In this review, we highlight key gaps in knowledge, discuss the heterogeneity of neutrophils during the evolution of the disease, how they can contribute to COVID\u201019 pathogenesis, and potential therapeutic strategies that target neutrophil\u2010mediated inflammatory responses.<\/jats:p>","DOI":"10.1111\/imr.13175","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T10:53:35Z","timestamp":1669632815000},"page":"399-412","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Neutrophils during <scp>SARS\u2010CoV<\/scp>\u20102 infection: Friend or foe?"],"prefix":"10.1111","volume":"314","author":[{"given":"Fernanda V. 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