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This process is marked by a series of checkpoints: T\u2010lineage commitment, T\u2010cell receptor (TCR)\u03b2 selection, and positive and negative selection. Dynamically changing combinations of TFs drive differentiation along the T\u2010lineage trajectory, through mechanisms that have been most extensively dissected in adult mouse T\u2010lineage cells. However, fetal T\u2010cell development differs from adult in ways that suggest that these TF mechanisms are not fully deterministic. The first wave of fetal T\u2010cell differentiation occurs during a unique developmental window during thymic morphogenesis, shows more rapid kinetics of differentiation with fewer rounds of cell division, and gives rise to unique populations of innate lymphoid cells (ILCs) and invariant \u03b3\u03b4T cells that are not generated in the adult thymus. As the characteristic kinetics and progeny biases are cell\u2010intrinsic properties of thymic progenitors, the differences could be based on distinct TF network circuitry within the progenitors themselves. Here, we review recent single\u2010cell transcriptome data that illuminate the TF networks involved in T\u2010cell differentiation in the fetal and adult mouse thymus.<\/jats:p>","DOI":"10.1111\/imr.13190","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T12:53:27Z","timestamp":1675256007000},"page":"171-196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Speed and navigation control of thymocyte development by the fetal T\u2010cell gene regulatory network"],"prefix":"10.1111","volume":"315","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1827-0247","authenticated-orcid":false,"given":"Brendan W.","family":"MacNabb","sequence":"first","affiliation":[{"name":"Division of Biology &amp; Biological Engineering California Institute of Technology  Pasadena California 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