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These lipid mediators, being unstable in vivo, act locally at their production sites; thus, their physiological functions remain unclear. However, recent pharmacological and genetic approaches using experimental murine models have provided significant insights into the roles of these lipid mediators in various pathophysiological conditions, including cutaneous inflammatory diseases. These lipid mediators act not only through signaling by themselves but also by potentiating the signaling of other chemical mediators, such as cytokines and chemokines. For instance, prostaglandin\n                    <jats:styled-content style=\"fixed-case\">\n                      E\n                      <jats:sub>2<\/jats:sub>\n                      \u2010EP4\n                    <\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">\n                      LTB\n                      <jats:sub>4<\/jats:sub>\n                      \u2010BLT1\n                    <\/jats:styled-content>\n                    signaling on cutaneous dendritic cells substantially facilitate their chemokine\u2010induced migration ability into the skin and play critical roles in the priming and\/or activation of antigen\u2010specific effector T cells in the skin. In addition to these \u03c96 fatty acid\u2010derived metabolites, various \u03c93 fatty acid\u2010derived metabolites regulate skin immune cell functions, and some exert potent anti\u2010inflammatory functions. Lipid mediators act as modulators of cutaneous immune responses, and manipulating the signaling from lipid mediators has the potential as a novel therapeutic approach for human skin diseases.\n                  <\/jats:p>","DOI":"10.1111\/imr.13193","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T07:36:50Z","timestamp":1677137810000},"page":"95-112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Exploring the roles of prostanoids, leukotriens, and dietary fatty acids in cutaneous inflammatory diseases: Insights from pharmacological and genetic approaches"],"prefix":"10.1111","volume":"317","author":[{"given":"Tetsuya","family":"Honda","sequence":"first","affiliation":[{"name":"Department of Dermatology Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0773-0554","authenticated-orcid":false,"given":"Kenji","family":"Kabashima","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyoto University Graduate School of Medicine  Kyoto Japan"},{"name":"Singapore Immunology Network (SIgN), Agency for Science, Technology, and Research (A*STAR), Biopolis  Singapore Singapore"},{"name":"5. 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