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Here, we focus on the function of one G\u2010protein coupled receptor, GPR35, in neutrophil recruitment. GPR35 has been challenging to study due the description of multiple ligands and G\u2010protein couplings. Recently, we found that GPR35\u2010expressing hematopoietic cells respond to the serotonin metabolite 5\u2010hydroxyindoleacetic acid (5\u2010HIAA). We discuss distinct response profiles of GPR35 to 5\u2010HIAA compared to other ligands. To place the functions of 5\u2010HIAA in context, we summarize the actions of serotonin in vascular biology and leukocyte recruitment. Important sources of serotonin and 5\u2010HIAA are platelets and mast cells. We discuss the dynamics of cell migration into inflamed tissues and how multiple platelet and mast cell\u2010derived mediators, including 5\u2010HIAA, cooperate to promote neutrophil recruitment. Additional actions of GPR35 in tissue physiology are reviewed. Finally, we discuss how clinically approved drugs that modulate serotonin uptake and metabolism may influence 5\u2010HIAA\u2010GPR35 function, and we speculate about broader influences of the GPR35 ligand\u2010receptor system in immunity and disease.<\/jats:p>","DOI":"10.1111\/imr.13194","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T12:34:39Z","timestamp":1678970079000},"page":"187-202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["<scp>GPR35<\/scp> and mediators from platelets and mast cells in neutrophil migration and inflammation"],"prefix":"10.1111","volume":"317","author":[{"given":"Marco","family":"De\u00a0Giovanni","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Howard Hughes Medical Institute University of California, San Francisco  San Francisco California 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