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We cloned the high\u2010 and low\u2010affinity LTB<jats:sub>4<\/jats:sub> receptors, BLT1 and BLT2, respectively, and examined their functions by generating and studying gene\u2010targeted mice. BLT1 is involved in the pathogenesis of various inflammatory and immune diseases, including asthma, psoriasis, contact dermatitis, allergic conjunctivitis, age\u2010related macular degeneration, and immune complex\u2010mediated glomerulonephritis. Meanwhile, BLT2 is a high\u2010affinity receptor for 12\u2010hydroxyheptadecatrienoic acid, which is involved in the maintenance of dermal and intestinal barrier function, and the acceleration of skin and corneal wound healing. 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