{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:39:47Z","timestamp":1791895187978,"version":"4.3.4"},"reference-count":242,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T00:00:00Z","timestamp":1680566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunological Reviews"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Rapid reaction to microbes invading mucosal tissues is key to protect the host against disease. Respiratory tissue\u2010resident memory T (T<jats:sub>RM<\/jats:sub>) cells provide superior immunity against pathogen infection and\/or re\u2010infection, due to their presence at the site of pathogen entry. However, there has been emerging evidence that exuberant T<jats:sub>RM<\/jats:sub>\u2010cell responses contribute to the development of various chronic respiratory conditions including pulmonary sequelae post\u2010acute viral infections. In this review, we have described the characteristics of respiratory T<jats:sub>RM<\/jats:sub> cells and processes underlying their development and maintenance. We have reviewed T<jats:sub>RM<\/jats:sub>\u2010cell protective functions against various respiratory pathogens as well as their pathological activities in chronic lung conditions including post\u2010viral pulmonary sequelae. Furthermore, we have discussed potential mechanisms regulating the pathological activity of T<jats:sub>RM<\/jats:sub> cells and proposed therapeutic strategies to alleviate T<jats:sub>RM<\/jats:sub>\u2010cell\u2010mediated lung immunopathology. We hope that this review provides insights toward the development of future vaccines or interventions that can harness the superior protective abilities of T<jats:sub>RM<\/jats:sub> cells, while minimizing the potential for immunopathology, a particularly important topic in the era of coronavirus disease 2019 (COVID\u201019) pandemic.<\/jats:p>","DOI":"10.1111\/imr.13201","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T12:15:54Z","timestamp":1680610554000},"page":"63-83","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Tissue\u2010resident memory T cells and lung immunopathology"],"prefix":"10.1111","volume":"316","author":[{"given":"In Su","family":"Cheon","sequence":"first","affiliation":[{"name":"Carter Immunology Center University of Virginia  Charlottesville Virginia USA"},{"name":"Division of Infectious Disease and International Health, Department of Medicine University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Min","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Systems Biotechnology Chung\u2010Ang University  Anseong Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2347-4511","authenticated-orcid":false,"given":"Jie","family":"Sun","sequence":"additional","affiliation":[{"name":"Carter Immunology Center University of Virginia  Charlottesville Virginia USA"},{"name":"Division of Infectious Disease and International Health, Department of Medicine University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3166"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2011.02.006"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.8.4254"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00329-14"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80573-7"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1929"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00170"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.02.010"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050137"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/44385"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1058867"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1718"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20090858"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.01.009"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad2035"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2744"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210417"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2019.05.011"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201682"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0313180"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abb6852"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-021-00461-z"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.08.019"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108661"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.912393"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010201107"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0711-8"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-022-00934-8"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11522"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02284"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04606"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3589"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.07.037"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402975"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20181308"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aaw1217"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2022.102278"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00400"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2745"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abo5871"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(04)00021-4"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202002566R"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abg3533"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032712-095954"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.08.019"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20160938"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-018-0003-x"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aam6970"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2014.133"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.11.008"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abc4557"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.03.004"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.06.087"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1101\/2022.09.13.507852"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002173"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1502337"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2209021119"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002613"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004204"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10092355"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2013.67"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102243"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abb6808"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902281"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190865"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201646575"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.07.032"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI142014"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abb5590"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27064-3"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(21)00180-4"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2118312119"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-03041-6"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00291-2"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2017.46"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.48"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010272"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200109)31:9<2574::AID-IMMU2574>3.0.CO;2-V"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.4049\/immunohorizons.2000067"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10224"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12486"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.68864"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.163.10.5535"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI96957"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016245"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.943331"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.08.013"},{"issue":"10","key":"e_1_2_12_89_1","article-title":"Vaccine\u2010generated lung tissue\u2010resident memory T cells provide heterosubtypic protection to influenza infection. JCI","volume":"1","author":"Zens KD","year":"2016","journal-title":"Insight"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02093"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01069-10"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.839455"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20192291"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.06.016"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2525"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800979"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02796-3"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0901-9"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-00455-9"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abl9105"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abk1741"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20202187"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2001400"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2100608"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.add4853"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abo2523"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2017.43"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-019-0218-5"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400019"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041370112"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abf1198"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0494-y"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-018-0094-4"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2262"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.22.012703.104716"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2870"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.11.004"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11492-7"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700257"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abg9296"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-3079"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aba6087"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aam9171"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00043"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110551"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30866-8"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI143226"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11656-5"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.10021"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aas9673"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00983-2020"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2021-0418OC"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-0873"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.05.011"},{"issue":"8","key":"e_1_2_12_135_1","first-page":"247","article-title":"Tissue resident memory T cells are increased in the lungs of COPD patients","volume":"8","author":"Richmond B","year":"2022","journal-title":"ERJ Open Research"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.12.8090"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.3109\/10799893.2011.631929"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.01.032"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0000000000000753"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00065004"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200808-080GO"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-8-168"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2020.02.127"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14101"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.931251"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abc8122"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000064210.92444.B5"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aav5581"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20212059"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.1.546"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000004216"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.05.001"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800671"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2015-0387LE"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2196"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133698"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abm7996"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01770"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.06.007"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-10-107"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.78074"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0223430"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.710375"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.11.056"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3862"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04444"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.663986"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12254-021-00756-8"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.08.078"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-7568(22)00245-8"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7121e1"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abf6692"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.50"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.05.088"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23333-3"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03233-8"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-021-02305-z"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.01.017"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2022030286"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01395-9"},{"issue":"11","key":"e_1_2_12_181_1","first-page":"S176","article-title":"Overview of idiopathic pulmonary fibrosis (IPF) and evidence\u2010based guidelines","volume":"23","author":"Sharif R","year":"2017","journal-title":"Am J Manag Care"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2002.01447.x"},{"key":"e_1_2_12_183_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri778"},{"key":"e_1_2_12_184_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20092017"},{"key":"e_1_2_12_185_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2014.106"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05542-y"},{"key":"e_1_2_12_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021.103012"},{"key":"e_1_2_12_188_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03631-y"},{"key":"e_1_2_12_189_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-00985-3"},{"key":"e_1_2_12_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.08.094"},{"key":"e_1_2_12_191_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24734-0"},{"key":"e_1_2_12_192_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1202288109"},{"key":"e_1_2_12_193_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9112457"},{"key":"e_1_2_12_194_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3108"},{"key":"e_1_2_12_195_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aag2031"},{"key":"e_1_2_12_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2022.02.009"},{"key":"e_1_2_12_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.04.007"},{"key":"e_1_2_12_198_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12464-3"},{"key":"e_1_2_12_199_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1507387112"},{"key":"e_1_2_12_200_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00176807"},{"key":"e_1_2_12_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.11.005"},{"key":"e_1_2_12_202_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abo0686"},{"key":"e_1_2_12_203_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2023.0743"},{"issue":"1","key":"e_1_2_12_204_1","first-page":"95","article-title":"Effect of Oral Nirmatrelvir on Long COVID symptoms: 4 cases and rationale for systematic studies","volume":"7","author":"Peluso MJ","year":"2022","journal-title":"Pathog Immun"},{"key":"e_1_2_12_205_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-260687"},{"key":"e_1_2_12_206_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.14.1667"},{"key":"e_1_2_12_207_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac228"},{"key":"e_1_2_12_208_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01840-0"},{"key":"e_1_2_12_209_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1902226"},{"key":"e_1_2_12_210_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2001100"},{"key":"e_1_2_12_211_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02182-2020"},{"key":"e_1_2_12_212_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni0217-246d"},{"key":"e_1_2_12_213_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.668207"},{"key":"e_1_2_12_214_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-0899-4_7"},{"key":"e_1_2_12_215_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.5680"},{"key":"e_1_2_12_216_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200601-008AW"},{"key":"e_1_2_12_217_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.01.018"},{"key":"e_1_2_12_218_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500777"},{"key":"e_1_2_12_219_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12715"},{"key":"e_1_2_12_220_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200109)31:9<2566::AID-IMMU2566>3.0.CO;2-L"},{"key":"e_1_2_12_221_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.11.025"},{"key":"e_1_2_12_222_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.74623"},{"key":"e_1_2_12_223_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel220"},{"key":"e_1_2_12_224_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-37132014000100012"},{"key":"e_1_2_12_225_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2010.11.002"},{"key":"e_1_2_12_226_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2005.07.007"},{"key":"e_1_2_12_227_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110456"},{"key":"e_1_2_12_228_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-03148-w"},{"key":"e_1_2_12_229_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiab490"},{"key":"e_1_2_12_230_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-01113-x"},{"key":"e_1_2_12_231_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.677707"},{"key":"e_1_2_12_232_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021484"},{"key":"e_1_2_12_233_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.12.008"},{"key":"e_1_2_12_234_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00002314"},{"key":"e_1_2_12_235_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1004081"},{"key":"e_1_2_12_236_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00301.2018"},{"key":"e_1_2_12_237_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111980"},{"key":"e_1_2_12_238_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.922422"},{"key":"e_1_2_12_239_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abo5795"},{"key":"e_1_2_12_240_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2020.08.038"},{"key":"e_1_2_12_241_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2020.06.001"},{"key":"e_1_2_12_242_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.706902"},{"key":"e_1_2_12_243_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1770"}],"container-title":["Immunological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imr.13201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T08:54:45Z","timestamp":1692262485000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imr.13201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,4]]},"references-count":242,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1111\/imr.13201"],"URL":"https:\/\/doi.org\/10.1111\/imr.13201","archive":["Portico"],"relation":{},"ISSN":["0105-2896","1600-065X"],"issn-type":[{"value":"0105-2896","type":"print"},{"value":"1600-065X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,4]]},"assertion":[{"value":"2023-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}