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The factors that govern T cell transit through inflamed tissues remain incompletely understood, but one important determinant of T cell exit from tissues is sphingosine 1\u2010phosphate (S1P) signaling. In homeostasis, S1P levels are high in blood and lymph compared to lymphoid organs, and lymphocytes follow S1P gradients out of tissues into circulation using varying combinations of five G\u2010protein coupled S1P receptors. During an immune response, both the shape of S1P gradients and the expression of S1P receptors are dynamically regulated. Here we review what is known, and key questions that remain unanswered, about how S1P signaling is regulated in inflammation and in turn how S1P shapes immune responses.<\/jats:p>","DOI":"10.1111\/imr.13219","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T08:43:36Z","timestamp":1684745016000},"page":"8-19","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Get me out of here: <scp>Sphingosine 1\u2010phosphate<\/scp> signaling and T cell exit from tissues during an immune response"],"prefix":"10.1111","volume":"317","author":[{"given":"Victoria M.","family":"Hallisey","sequence":"first","affiliation":[{"name":"Department of Cell Biology New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0834-0822","authenticated-orcid":false,"given":"Susan 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