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However, immune checkpoint inhibitors (ICI) can also lead to a breach in self\u2010tolerance resulting in immune\u2010related adverse events (irAEs) that include tissue\u2010specific autoimmunity. This review addresses the question of whether the mechanisms that drive ICI\u2010induced irAEs are shared or distinct with those driving spontaneous autoimmunity, focusing on ICI\u2010induced diabetes, ICI\u2010induced arthritis, and ICI\u2010induced thyroiditis due to the wealth of knowledge about the development of autoimmunity in type 1 diabetes, rheumatoid arthritis, and Hashimoto's thyroiditis. It reviews current knowledge about role of genetics and autoantibodies in the development of ICI\u2010induced irAEs and presents new studies utilizing single\u2010cell omics approaches to identify T\u2010cell signatures associated with ICI\u2010induced irAEs. Collectively, these studies indicate that there are similarities and differences between ICI\u2010induced irAEs and autoimmune disease and that studying them in parallel will provide important insight into the mechanisms critical for maintaining immune tolerance.<\/jats:p>","DOI":"10.1111\/imr.13247","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T07:44:46Z","timestamp":1690357486000},"page":"81-88","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Immune\u2010related adverse events after immune check point inhibitors: Understanding the intersection with autoimmunity"],"prefix":"10.1111","volume":"318","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7149-363X","authenticated-orcid":false,"given":"Namrata","family":"Singh","sequence":"first","affiliation":[{"name":"Division of Rheumatology University of Washington  Seattle Washington 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