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While the number of phagocytic events achieved by a single phagocyte can be remarkable, exceeding hundreds per day, the same phagocytic cells are relatively long\u2010lived. It should therefore be obvious that phagocytic meals must be resolved in order to maintain the responsiveness of the phagocyte and to avoid storage defects. In this article, we discuss the mechanisms involved in the resolution process, including solute transport pathways and membrane traffic. We describe how products liberated in phagolysosomes support phagocyte metabolism and the immune response. We also speculate on mechanisms involved in the redistribution of phagosomal metabolites back to circulation. Finally, we highlight the pathologies owed to impaired phagosome resolution, which range from storage disorders to neurodegenerative diseases.<\/jats:p>","DOI":"10.1111\/imr.13260","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T12:01:41Z","timestamp":1691496101000},"page":"45-64","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The resolution of phagosomes"],"prefix":"10.1111","volume":"319","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1164-5248","authenticated-orcid":false,"given":"Sivakami","family":"Mylvaganam","sequence":"first","affiliation":[{"name":"Program in Cell Biology Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Department of Biochemistry University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3455-3714","authenticated-orcid":false,"given":"Spencer 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